Department of Photodynamic, Medical Laser Research Center, YARA Institute, ACECR, Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Expert Opin Drug Deliv. 2021 Feb;18(2):265-272. doi: 10.1080/17425247.2021.1829591. Epub 2020 Oct 19.
COVID-19 disease has shocked the world by its spread and contagiousness. At this time, there is no valid vaccine and no proven drug treatment for COVID-19 patients. Current treatments are focused on Oxygenation, Cytokine Storm management, anti-inflammatory effects, and antiviral therapy. Antiviral photodynamic therapy (aPDT) is based on the reaction between a photo-sensitive agent and a light source in the presence of oxygen which can produce oxidative and free radical agents to damage the virus' structures. Recent studies show that nanotechnology can improve aPDT's outcome. The aim of this study was to find out the potential therapeutic effects of Nano antiviral photodynamic therapy on COVID-19.
This review evaluates Nano Antiviral Photodynamic Therapy: A Probable Biophysicochemical Management Modality in SARS-CoV-2. Data were extracted from published different studies published on PUBMED, SCOPUS, and Web of Science.
Studies indicating that aPDT and Nano-based aPDT can be useful in viral pulmonary complications like Influenza, SARS-CoV, and MERS, but there was no direct study on SARS-Cov-2. Recent studies showed that Nano-based aPDT could relate to control of the stages of viral infections. Altogether, further investigations for the application of nanomedicine in antimicrobial photodynamic inactivation are needed for COVID-19 Management.
COVID-19 疾病以其传播性和传染性震惊了世界。此时，针对 COVID-19 患者尚无有效的疫苗和经过验证的药物治疗方法。目前的治疗方法集中在氧合、细胞因子风暴管理、抗炎作用和抗病毒治疗上。光动力疗法（aPDT）是基于在氧气存在的情况下光敏剂与光源之间的反应，可产生氧化和自由基物质来破坏病毒结构。最近的研究表明，纳米技术可以提高 aPDT 的效果。本研究旨在探讨纳米抗病毒光动力疗法治疗 COVID-19 的潜在治疗效果。
本文评价了纳米抗病毒光动力疗法：SARS-CoV-2 的一种可能的生物物理化学治疗方法。数据取自 PUBMED、SCOPUS 和 Web of Science 上发表的不同研究。
研究表明 aPDT 和基于纳米的 aPDT 可用于治疗流感、SARS-CoV 和 MERS 等病毒性肺部并发症，但尚无针对 SARS-CoV-2 的直接研究。最近的研究表明，基于纳米的 aPDT 可能与控制病毒感染阶段有关。总之，需要进一步研究纳米医学在抗菌光动力失活中的应用，以管理 COVID-19。
