School of Dentistry, Ibirapuera University (UNIB), São Paulo, SP, Brazil.
CAES - Military Police of São Paulo State, São Paulo, SP, Brazil.
Photodiagnosis Photodyn Ther. 2022 Jun;38:102762. doi: 10.1016/j.pdpdt.2022.102762. Epub 2022 Feb 16.
Emerging variants of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) may have an impact on the virus's transmissibility and pathogenicity and an increased risk of reinfection. Antimicrobial photodynamic therapy (aPDT) is a promising technique to decontaminate the oral cavity to minimize and inactivate microorganisms' load. This article reports through a case series, a proposal for efficient oral decontamination for hospitalized patients with COVID 19 using aPDT. Samples of oral tissues were obtained after aPDT and analyzed using two methods of RT-qPCR to elucidate qualitative and quantitative viral profiles of SARS-CoV-2 RNA in the oral cavity. There was a reduction of viral load in the oral cavity immediately or one hour after the use of aPDT. This method could be a good option to decontaminate the oral cavity to minimize and inactivate microorganism load.
严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）的新兴变体可能会影响病毒的传染性和致病性，并增加再次感染的风险。光动力抗菌疗法（aPDT）是一种很有前途的口腔消毒技术，可以最大程度地减少和灭活微生物的负荷。本文通过一系列病例报告，提出了一种使用 aPDT 对 COVID-19 住院患者进行有效口腔消毒的建议。在 aPDT 后获得口腔组织样本，并使用两种 RT-qPCR 方法对口腔中 SARS-CoV-2 RNA 的定性和定量病毒谱进行分析。在使用 aPDT 后即刻或一小时后，口腔中的病毒载量降低。该方法可能是一种对口腔进行消毒以最大程度地减少和灭活微生物负荷的好方法。
