Junaid Md, Akter Yeasmin, Afrose Syeda Samira, Tania Mousumi, Khan Md Asaduzzaman
Molecular Modeling Drug-design and Discovery Laboratory, Pharmacology Research Division, Bangladesh Council of Scientific and Industrial Research, Chattogram, Bangladesh.
Department of Biotechnology and Genetic Engineering, Noakhali Science & Technology University, Noakhali, Bangladesh.
Mini Rev Med Chem. 2021;21(3):288-301. doi: 10.2174/1389557520666201005143818.
AKT/PKB is an important enzyme with numerous biological functions, and its overexpression is related to carcinogenesis. AKT stimulates different signaling pathways that are downstream of activated tyrosine kinases and phosphatidylinositol 3-kinase, hence functions as an important target for anti-cancer drugs.
In this review article, we have interpreted the role of AKT signaling pathway in cancer and the natural inhibitory effect of Thymoquinone (TQ) in AKT and its possible mechanisms.
We have collected the updated information and data on AKT, its role in cancer and the inhibitory effect of TQ in AKT signaling pathway from Google Scholar, PubMed, Web of Science, Elsevier, Scopus, and many more.
Many drugs are already developed, which can target AKT, but very few among them have passed clinical trials. TQ is a natural compound, mainly found in black cumin, which has been found to have potential anti-cancer activities. TQ targets numerous signaling pathways, including AKT, in different cancers. In fact, many studies revealed that AKT is one of the major targets of TQ. The preclinical success of TQ suggests its clinical studies on cancer.
This review article summarizes the role of AKT in carcinogenesis, its potent inhibitors in clinical trials, and how TQ acts as an inhibitor of AKT and TQ's future as a cancer therapeutic drug.
AKT/PKB是一种具有多种生物学功能的重要酶，其过表达与癌症发生有关。AKT刺激活化酪氨酸激酶和磷脂酰肌醇3激酶下游的不同信号通路，因此是抗癌药物的重要靶点。
在这篇综述文章中，我们阐述了AKT信号通路在癌症中的作用以及胸腺醌（TQ）对AKT的天然抑制作用及其可能机制。
我们从谷歌学术、PubMed、科学网、爱思唯尔、Scopus等收集了关于AKT及其在癌症中的作用以及TQ对AKT信号通路抑制作用的最新信息和数据。
已经开发出许多可靶向AKT的药物，但其中很少有通过临床试验的。TQ是一种天然化合物，主要存在于黑孜然中，已发现其具有潜在的抗癌活性。TQ在不同癌症中靶向多种信号通路，包括AKT。事实上，许多研究表明AKT是TQ的主要靶点之一。TQ的临床前成功表明其在癌症方面的临床研究前景。
这篇综述文章总结了AKT在癌症发生中的作用、其在临床试验中的有效抑制剂，以及TQ如何作为AKT的抑制剂以及TQ作为癌症治疗药物的未来前景。
