Department of Radiology, Medstar Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, DC, 20007.
Department of Radiology, Medstar Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, DC, 20007.
J Vasc Interv Radiol. 2020 Nov;31(11):1740-1744.e9. doi: 10.1016/j.jvir.2020.07.011. Epub 2020 Oct 2.
Advances in immunotherapy have changed the landscape of oncology over the past decade. Still, most patients with solid organ tumors do not derive a durable benefit from immunotherapies. How these tumors evade treatment has not been fully elucidated, but several studies are seeking ways to stimulate treatment response in these immunologically quiescent tumors. Of these, the combination of locoregional therapy with immune checkpoint inhibition is of interest to the interventional radiologist. This brief report provides an overview of current trials testing the effectiveness of locoregional therapy in combination with immune checkpoint inhibitors and identifies future research goals.
在过去的十年中，免疫疗法的进步改变了肿瘤学的格局。尽管如此，大多数实体器官肿瘤患者并未从免疫疗法中获得持久的益处。这些肿瘤如何逃避治疗尚未完全阐明，但有几项研究正在寻找刺激这些免疫静止肿瘤治疗反应的方法。在这些研究中，局部区域治疗与免疫检查点抑制联合应用引起了介入放射学家的兴趣。本简要报告概述了目前正在测试局部区域治疗联合免疫检查点抑制剂有效性的临床试验，并确定了未来的研究目标。
