用于局部区域性肝动脉治疗的肝细胞癌动物模型。
Animal Models of Hepatocellular Carcinoma for Local-Regional Intraarterial Therapies.
机构信息
From the Department of Radiology and Medical Imaging (V.M.C., L.R.W.) and Department of Microbiology, Immunology, and Cancer Biology (D.L.B.), University of Virginia Health Systems, 1215 Lee St, PO Box 800170, Charlottesville, VA 22908.
出版信息
Radiol Imaging Cancer. 2022 Jul;4(4):e210098. doi: 10.1148/rycan.210098.
Abstract
Animal models play a crucial role in developing and testing new therapies for hepatocellular carcinoma (HCC), providing preclinical evidence prior to exploring human safety and efficacy outcomes. The interventional radiologist must weigh the advantages and disadvantages of various animal models available when testing a new local-regional therapy. This review highlights the currently available animal models for testing local-regional therapies for HCC and details the importance of considering animal genetics, tumor biology, and molecular mechanisms when ultimately choosing an animal model. Animal Studies, Interventional-Vascular, Molecular Imaging-Clinical Translation, Molecular Imaging-Cancer, Chemoembolization, Liver © RSNA, 2022.
摘要
动物模型在开发和测试肝细胞癌 (HCC) 的新疗法方面发挥着至关重要的作用，为探索人类安全性和疗效结果之前提供临床前证据。在测试新的局部区域治疗方法时，介入放射学家必须权衡各种可用动物模型的优缺点。本文综述了目前用于测试 HCC 局部区域治疗的动物模型，并详细说明了在最终选择动物模型时考虑动物遗传学、肿瘤生物学和分子机制的重要性。动物研究、介入血管学、分子影像学-临床转化、分子影像学-癌症、化疗栓塞、肝脏©RSNA，2022 年。
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