微小膜壳绦虫在小鼠体内分化和成熟过程中表面抗原的变化

Changes in surface antigens of Hymenolepis nana during differentiation and maturation in mice.

作者信息

Ito A, Onitake K

出版信息

J Helminthol. 1987 Jun;61(2):129-36. doi: 10.1017/s0022149x00009871.

PMID:3302013

Abstract

The surface antigens of oncosphere, cysticercoid, adult scolex and adult strobila (other than scolex) of Hymenolepis nana differ critically from one another. When the oncosphere of H. nana undergoes differentiation and development into the mature tapeworm, the infected mouse first produces anti-oncosphere antibody, followed by anti-cysticercoid, anti-adult scolex and finally anti-strobila (other than scolex region) antibodies of IgG, IgM and IgA isotypes as detected by indirect immunofluorescent antibody test. The parasite changed its surface antigens throughout its differentiation and maturation, and all developmental stages were recognized by the infected mouse host. However, there appeared no further changes in surface antigens during aging after maturation. The antibody responses were always delayed compared with the differentiation and maturation of the parasite.

摘要

微小膜壳绦虫六钩蚴、似囊尾蚴、成虫头节和成虫节片（头节除外）的表面抗原彼此差异很大。当微小膜壳绦虫的六钩蚴分化发育为成熟绦虫时，感染的小鼠首先产生抗六钩蚴抗体，随后产生抗似囊尾蚴、抗成虫头节抗体，最后通过间接免疫荧光抗体试验检测到IgG、IgM和IgA同种型的抗节片（头节区域除外）抗体。寄生虫在其分化和成熟过程中改变了其表面抗原，并且所有发育阶段都被感染的小鼠宿主识别。然而，成熟后衰老过程中表面抗原没有进一步变化。与寄生虫的分化和成熟相比，抗体反应总是延迟的。