Ito A
Clin Exp Immunol. 1985 Apr;60(1):87-94.
Anti-parasite antibody responses were compared among several strains of mice experimentally infected with the dwarf tapeworm, Hymenolepis nana. The antibody titres were highly variable among the mouse strains in addition to variation in worm fecundity and longevity. The influence of the thymus on both infection and anti-parasite antibody production (especially of IgE isotype) was studied by the use of congenitally athymic (nu/nu) nude and their phenotypically normal (nu/+) CD-1(ICR) mice infected with H. nana. All nude (nu/nu) mice harboured fully mature 70 day old adult tapeworms of the first generation derived from eggs initially given on day 0. In addition, they contained (a) younger second generation adults derived from autoinfection and present in the intestinal lumen, (b) a number of abnormally large (about 1-2 mm in diameter) balloon like, fluid filled cysticercoids in not only the intestinal tissue but also parenteral tissues such as the mesenteric lymph nodes, liver and lung, and (c) normal cysticercoids derived from challenging eggs in the intestinal tissue. Infected nude mice produced no antibodies detectable by PCA (IgE) and double diffusion (IgG) tests. In contrast, normal (nu/+) mice and nude mice reconstituted with thymocytes expelled almost all luminal adults of the primary infection by day 70 and produced antibodies to extracts of adult H. nana. Neither autoinfection nor reinfection following egg challenge occurred in any of these normal (nu/+) and reconstituted nude mice. Therefore, acquired immune responses against H. nana (as assessed by resistance not only to the tissue phase measured by the failure of tissue cysticercoid recovery from egg challenge, but also to the lumen phase assessed by the failure of autoinfection adult recovery and 'worm expulsion' of the initially established adults) are all thymus-dependent in mice. The antibody responses examined are also thymus-dependent.
对几种经微小膜壳绦虫实验感染的小鼠品系的抗寄生虫抗体反应进行了比较。除了虫体繁殖力和寿命的差异外，抗体滴度在小鼠品系间也存在很大差异。利用先天性无胸腺（nu/nu）裸鼠及其表型正常（nu/+）的CD-1（ICR）小鼠感染微小膜壳绦虫，研究了胸腺对感染和抗寄生虫抗体产生（尤其是IgE同种型）的影响。所有裸鼠（nu/nu）均携带来自第0天最初给予的虫卵发育而来的第一代完全成熟的70日龄成虫绦虫。此外，它们还含有：（a）来自自身感染且存在于肠腔中的较年轻的第二代成虫；（b）不仅在肠组织中，而且在肠系膜淋巴结、肝脏和肺等非肠道组织中存在的一些异常大（直径约1 - 2毫米）、呈气球状、充满液体的似囊尾蚴；（c）来自肠道组织中激发虫卵的正常似囊尾蚴。感染的裸鼠通过PCA（IgE）和双向扩散（IgG）试验检测不到抗体。相比之下，正常（nu/+）小鼠和用胸腺细胞重建的裸鼠在第70天时几乎排出了原发性感染的所有肠腔成虫，并产生了针对微小膜壳绦虫成虫提取物的抗体。在这些正常（nu/+）小鼠和重建的裸鼠中，均未发生自身感染或虫卵激发后的再感染。因此，小鼠对微小膜壳绦虫的获得性免疫反应（不仅通过对虫卵激发后组织似囊尾蚴恢复失败所测量的组织期的抵抗力，而且通过对自身感染成虫恢复失败和最初建立的成虫“驱虫”所评估的肠腔期的抵抗力来评估）均依赖于胸腺。所检测的抗体反应也依赖于胸腺。
