HIV 感染者单次接种甲型肝炎疫苗后免疫应答率低。
Low immune response rate of HIV-infected patients to a single injection of hepatitis A vaccine.
机构信息
Inserm, laboratoire de virologie, institut Pierre-Louis d'épidémiologie et de Santé Publique (iPLESP), hôpital Pitié-Salpêtrière, Sorbonne Université, AP-HP, 75013 Paris, France.
Inserm, service de maladies infectieuses et tropicales, institut Pierre-Louis d'épidémiologie et de Santé Publique (iPLESP), hôpital Pitié-Salpêtrière, Sorbonne Université, AP-HP, 75013 Paris, France.
出版信息
Infect Dis Now. 2021 Feb;51(1):94-96. doi: 10.1016/j.medmal.2020.09.016. Epub 2020 Oct 3.
OBJECTIVES
We aimed to evaluate the immune response of HIV-1 positive patients to a single injection of HAV vaccine in a context of vaccine shortage during the 2017 European outbreak.
METHODS
We retrospectively enrolled all HIV-1 positive patients vaccinated by a single injection of HAV vaccine Vaqta 50®. HAV serology was performed before and>30 days after the vaccine injection.
RESULTS
Among the 73 patients, HIV-1 viral load was≤50 copies/mL in 93.2% of the cases. Medians of CD4 and median ratio of T CD4/CD8 cells were 658/mm and 0.9, respectively. A low immune response rate (59.7%) was observed among the patients. Responders had a significantly higher CD4/CD8 cell ratio than non-responders.
CONCLUSIONS
A serologic control should be recommended in this population in the event of a single injection vaccination schedule. During routine follow-up, and prior to any untoward event, physicians should assess the vaccination coverage of HIV-infected patients.
目的
在 2017 年欧洲爆发期间疫苗短缺的情况下，我们旨在评估 HIV-1 阳性患者对单次注射甲型肝炎（HAV）疫苗的免疫反应。
方法
我们回顾性地纳入了所有接受 Vaqta 50® 单次注射 HAV 疫苗接种的 HIV-1 阳性患者。在疫苗注射前和>30 天后进行 HAV 血清学检测。
结果
在 73 例患者中，93.2%的患者 HIV-1 病毒载量≤50 拷贝/ml。CD4 的中位数和 T 细胞 CD4/CD8 细胞的中位数比值分别为 658/mm 和 0.9。患者的免疫反应率较低（59.7%）。应答者的 CD4/CD8 细胞比值明显高于无应答者。
结论
在这种情况下，对于单次注射疫苗接种方案，应建议进行血清学监测。在常规随访中，并且在任何不良事件发生之前，医生应评估 HIV 感染患者的疫苗接种覆盖率。
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