Bowman Catharine, Piedalue Katherine-Ann, Baydoun Mohamad, Carlson Linda E
Department of Oncology, Division of Psychosocial Oncology University of Calgary Cumming School of Medicine, Calgary, AB T2S, Canada.
J Clin Med. 2020 Oct 2;9(10):3200. doi: 10.3390/jcm9103200.
Lower-extremity lymphedema (LEL) is a progressive, lifelong complication of cancer that places a substantial burden upon cancer survivors' quality of life (QOL) and psychosocial well-being. Despite its prevalence, cancer-related LEL is inconsistently diagnosed, treated, and poorly recognized by health care professionals. The purpose of this systematic review was to summarize and appraise the quantitative literature evaluating the impact of cancer-related LEL on patients' psychosocial well-being and QOL. Three databases (PubMed, PROQuest, and Scopus) were searched for observational research articles published before May 1st, 2020. Twenty-one articles were eligible (cross-sectional ( = 16), prospective cohort designs ( = 3), and retrospective cohort designs ( = 2)). The majority of studies reported a negative relationship between cancer-related LEL and global QOL and/or one or more psychosocial domains including (1) physical and functional; (2) psycho-emotional; (3) social, relational and financial. A greater number of LEL symptoms and higher LEL severity were associated with poorer QOL. Although the evidence to date suggests a negative relationship between cancer-related LEL and patients' QOL and psychosocial well-being, there is a substantial need for longitudinal analyses to examine the directionality and temporality of this effect in order to inform cancer survivorship care modelling and improve patient outcomes after cancer.
下肢淋巴水肿（LEL）是癌症一种渐进性的、伴随终身的并发症，给癌症幸存者的生活质量（QOL）和心理社会幸福感带来了沉重负担。尽管其发病率较高，但医疗保健专业人员对与癌症相关的LEL诊断不一致、治疗方法不一，且认识不足。本系统综述的目的是总结和评估定量文献，以评价与癌症相关的LEL对患者心理社会幸福感和生活质量的影响。检索了三个数据库（PubMed、PROQuest和Scopus），查找2020年5月1日前发表的观察性研究文章。有21篇文章符合条件（横断面研究（n = 16）、前瞻性队列设计（n = 3）和回顾性队列设计（n = 2））。大多数研究报告称，与癌症相关的LEL与总体生活质量和/或一个或多个心理社会领域之间存在负相关，这些领域包括：（1）身体和功能；（2）心理情绪；（3）社会、人际关系和经济。更多的淋巴水肿症状和更高的淋巴水肿严重程度与较差的生活质量相关。尽管迄今为止的证据表明与癌症相关的LEL与患者的生活质量和心理社会幸福感之间存在负相关，但仍迫切需要进行纵向分析，以研究这种影响的方向性和时间性，从而为癌症幸存者护理模式提供信息，并改善癌症患者的预后。
