Department of Anatomy, Université du Québec à Trois-Rivières, 3351 Boul. Des Forges, C.P. 500, Trois-Rivières, QC, G9A 5H7, Canada.
CogNAC Research Group, Université du Québec à Trois-Rivières, 3351 Boul. Des Forges, C.P. 500, Trois-Rivières, QC, G9A 5H7, Canada.
J Physiol Sci. 2020 Oct 6;70(1):46. doi: 10.1186/s12576-020-00774-x.
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder associated with chronic abdominal pain and altered pain processing. The aim of this study was to examine whether attentional processes contribute to altered pain inhibition processes in patients with IBS. Nine female patients with IBS and nine age-/sex-matched controls were included in a pain inhibition paradigm using counter-stimulation and distraction with electroencephalography. Patients with IBS showed no inhibition of pain-related brain activity by heterotopic noxious counter-stimulation (HNCS) or selective attention. In the control group, HNCS and selective attention decreased the N100, P260 and high-gamma oscillation power. In addition, pain-related high-gamma power in sensorimotor, anterior cingulate and left dorsolateral prefrontal cortex was decreased by HNCS and selective attention in the control group, but not in patients with IBS. These results indicate that the central pain inhibition deficit in IBS reflects interactions between several brain processes related to pain and attention.
肠易激综合征（IBS）是一种与慢性腹痛和疼痛处理改变相关的功能性胃肠疾病。本研究旨在探讨注意力过程是否有助于 IBS 患者疼痛抑制过程的改变。采用脑电图的对侧刺激和分心，纳入了 9 名 IBS 女性患者和 9 名年龄/性别匹配的对照者，进行疼痛抑制范式。IBS 患者的异源性伤害性对侧刺激（HNCS）或选择性注意均不能抑制与疼痛相关的大脑活动。在对照组中，HNCS 和选择性注意降低了 N100、P260 和高伽马振荡功率。此外，在对照组中，HNCS 和选择性注意降低了感觉运动、前扣带回和左侧背外侧前额叶皮质的疼痛相关高伽马功率，但在 IBS 患者中则没有。这些结果表明，IBS 中的中枢疼痛抑制缺陷反映了与疼痛和注意力相关的几个大脑过程之间的相互作用。
