Department of Pediatrics, Wayne State University, Detroit, MI, USA.
Department of Pediatrics, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, RI, USA.
J Perinatol. 2021 May;41(5):1014-1024. doi: 10.1038/s41372-020-00847-0. Epub 2020 Oct 6.
The objective of this paper is to compare in-hospital survival and survival without major morbidities in extremely preterm infants in relation to maternal body mass index (BMI).
This retrospective cohort study included extremely preterm infants (gestational age 22-28 weeks). This study was conducted at National Institute of Child Health and Human Development Neonatal Research Network sites. Primary outcome was survival without any major morbidity.
Maternal BMI data were available for 2415 infants. Survival without any major morbidity was not different between groups: 30.8% in the underweight/normal, 28.1% in the overweight, and 28.5% in the obese (P = 0.65). However, survival was lower in the obese group (76.5%) compared with overweight group (83.2%) (P = 0.02). Each unit increase in maternal BMI was associated with decreased odds of infant survival (P < 0.01).
Survival without any major morbidity was not associated with maternal obesity. An increase in maternal prepregnancy BMI was associated with decreased odds of infant survival.
本研究旨在比较极低出生体重儿（胎龄 22-28 周）与母体体重指数（BMI）相关的住院生存率和无重大并发症生存率。
本回顾性队列研究纳入了极低出生体重儿。本研究在国家儿童健康与人类发展研究所新生儿研究网络站点进行。主要结局是无重大并发症生存率。
本研究共纳入 2415 例患儿，其中 2415 例患儿的母亲 BMI 数据可用。各组间无重大并发症生存率无差异：低体重/正常体重组为 30.8%，超重组为 28.1%，肥胖组为 28.5%（P=0.65）。然而，肥胖组的存活率（76.5%）低于超重组（83.2%）（P=0.02）。母体 BMI 每增加一个单位，婴儿存活率的几率就会降低（P<0.01）。
无重大并发症生存率与母体肥胖无关。母体孕前 BMI 的增加与婴儿存活率的降低有关。
