School of Ophthalmology and Optometry, Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
State Key Laboratory of Optometry, Ophthalmology, and Vision Science, Affiliated Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Eye (Lond). 2021 Jul;35(7):1993-1998. doi: 10.1038/s41433-020-01210-5. Epub 2020 Oct 6.
To evaluate the microvasculature alterations in convalescent Vogt-Koyanagi-Harada (VKH) disease using optical coherence tomography angiography (OCTA), and to explore the association between microvasculature and the presence of sunset glow fundus (SGF).
A cross-sectional study was conducted with 28 VKH patients at convalescent stage and 25 healthy individuals. Both eyes of each participant were enrolled. The VKH patients were classified into two subgroups based on the existence of SGF. OCTA images (3 × 3 mm) were assessed for the data of superficial capillaris plexus (SCP), deep capillaris plexus (DCP), choriocapillaris, and foveal avascular zone (FAZ).
Compared with healthy control eyes and eyes without SGF, the vessel densities of the SCP and DCP decreased significantly in most regions of eyes with SGF (p < 0.0167). No significant difference of vascular perfusion was found between eyes without SGF and control eyes (p > 0.05). VKH patients with SGF had slightly increased FAZ area (p = 0.067) and decreased choroid flow area (p = 0.427) than those in the control group.
Convalescent VKH patients with SGF showed decreased macular capillary perfusion. OCTA could serve as a sensitive tool to assess the microvasculature alterations of VKH disease.
利用光相干断层扫描血管造影术（OCTA）评估恢复期 Vogt-小柳原田病（VKH）的微血管改变，并探讨微血管与晚霞状眼底（SGF）存在之间的关系。
本研究为横断面研究，共纳入 28 例恢复期 VKH 患者和 25 名健康对照者。每位参与者的双眼均纳入研究。根据 SGF 的存在，将 VKH 患者分为两组。评估 OCTA 图像（3×3mm）的浅层毛细血管丛（SCP）、深层毛细血管丛（DCP）、脉络膜毛细血管和黄斑中心无血管区（FAZ）的数据。
与健康对照组和无 SGF 组相比，有 SGF 的眼中，SCP 和 DCP 的血管密度在大多数区域均显著降低（p<0.0167）。无 SGF 的眼与对照组之间的血管灌注无显著差异（p>0.05）。与对照组相比，有 SGF 的 VKH 患者的 FAZ 面积略有增加（p=0.067），脉络膜血流面积减小（p=0.427）。
有 SGF 的恢复期 VKH 患者表现为黄斑毛细血管灌注减少。OCTA 可作为评估 VKH 病微血管改变的敏感工具。
