Jia S S, Zhao C, Gong D, Chen Z, Zhang M F
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Zhonghua Yan Ke Za Zhi. 2017 Oct 11;53(10):735-739. doi: 10.3760/cma.j.issn.0412-4081.2017.10.004.
To measure vascular density in retinal and choroidal capillary layers by optical coherence tomography angiography (OCTA) and to explore their potential clinical values in Vogt-Koyanagi-Harada disease (VKH). This is a cross-sectional case-control study. Twenty-one acute VKH cases presented to Peking Union Medical College Hospital between April 2015 and July 2015 and 49 healthy controls were enrolled in this study. OCTA was performed with a split-spectrum amplitude-decorrelation angiography-optical coherence tomography (SSADA-OCT) system borrowed from Optovue Inc. Vascular densities of the capillary layers were analyzed by the built-in software. Bilateral independent sample -test was used to compare retinal and choroidal vascular density of eyes in acute phase VKH with healthy controls. Spearman correlation test was used to analyze the correlation between the vascular density of retina and choroid in acute phase VKH and LogMAR best corrected visual acuity (BCVA). Mean vascular density of superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) in eyes of the acute VKH group were statistically lower than those of healthy control group (51.56%±2.88%, 56.51%±2.31%, 58.14%±2.10% . 53.55%±2.51%, 58.14%±2.10%, 58.14%±2.10%, 3.890, 3.910,-6.554, all 3 values were<0.01). In VKH patients, eyes with retinal detachment (RD) had statistically lower mean vascular density in the CC layer than those without (NRD) (63.46%±2.19% . 65.85%±1.79%, 3.890, 0.01), while no statistically significant differences were found in vascular densities of SCP and DCP layers between RD and NRD eyes. Spearman's correlation test revealed a negative correlation between vascular density of the CC layer and logMAR BCVA(=-0.437, 0.01), while no statistically significant associations were found between logMAR BCVA and vascular densities of SCP and DCP. OCTA can be used for quantitative detection of vascular density of retina and choroidal capillary in acute VKH. There is circulatory disturbance in SCP, DCP and CC of acute VKH. Vascular density of CC is associated with visual acuity and retinal detachment. .
通过光学相干断层扫描血管造影（OCTA）测量视网膜和脉络膜毛细血管层的血管密度，并探讨其在Vogt-小柳-原田病（VKH）中的潜在临床价值。这是一项横断面病例对照研究。2015年4月至2015年7月期间，21例急性VKH患者到北京协和医院就诊，本研究纳入了49名健康对照者。使用从Optovue公司借来的分裂光谱幅度去相关血管造影光学相干断层扫描（SSADA-OCT）系统进行OCTA检查。通过内置软件分析毛细血管层的血管密度。采用双侧独立样本t检验比较急性期VKH患者与健康对照者眼睛的视网膜和脉络膜血管密度。采用Spearman相关检验分析急性期VKH患者视网膜和脉络膜血管密度与最佳矫正视力（BCVA）的LogMAR值之间的相关性。急性VKH组患者眼睛的浅表毛细血管丛（SCP）、深层毛细血管丛（DCP）和脉络膜毛细血管（CC）的平均血管密度在统计学上低于健康对照组（51.56%±2.88%，56.51%±2.31%，58.14%±2.10%；53.55%±2.51%，58.14%±2.10%，58.14%±2.10%；t值分别为3.890、3.910、-6.554，所有3个值均<0.01）。在VKH患者中，发生视网膜脱离（RD）的眼睛CC层的平均血管密度在统计学上低于未发生视网膜脱离（NRD）的眼睛（63.46%±2.19%；65.85%±1.79%；t值为3.890，P=0.01），而RD和NRD眼睛的SCP和DCP层血管密度在统计学上无显著差异。Spearman相关检验显示CC层血管密度与LogMAR BCVA呈负相关（r=-0.437，P=0.01），而LogMAR BCVA与SCP和DCP的血管密度之间未发现统计学上的显著关联。OCTA可用于急性期VKH患者视网膜和脉络膜毛细血管血管密度的定量检测。急性VKH患者的SCP、DCP和CC存在循环障碍。CC的血管密度与视力和视网膜脱离有关。
