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与其他肺炎相比，急性新冠肺炎肺炎患者的高凝状态更为严重。

More Severe Hypercoagulable State in Acute COVID-19 Pneumonia as Compared With Other Pneumonia.

作者信息

Spiezia Luca, Campello Elena, Cola Marco, Poletto Francesco, Cerruti Lorenzo, Poretto Anna, Simion Chiara, Cattelan Annamaria, Vettor Roberto, Simioni Paolo

机构信息

General Internal Medicine and Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, Padova University Hospital, Padova, Italy.

Infectious Diseases, Padova University Hospital, Padova, Italy.

出版信息

Mayo Clin Proc Innov Qual Outcomes. 2020 Dec;4(6):696-702. doi: 10.1016/j.mayocpiqo.2020.09.002. Epub 2020 Oct 1.

DOI:10.1016/j.mayocpiqo.2020.09.002
PMID:33024937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7528900/
Abstract

OBJECTIVE

To conduct a comprehensive evaluation of coagulation profiles-via traditional and whole blood thromboelastometry tests-in coronavirus disease 2019 (COVID-19)-positive vs COVID-19-negative patients admitted to medical wards for acute pneumonia.

PATIENTS AND METHODS

We enrolled all consecutive patients admitted to internal medicine wards of Padova University Hospital between 7 March and 30 April, 2020, for COVID-19-related pneumonia (cases) vs non-COVID-19 pneumonia (controls). A group of healthy individuals acted as baseline for thromboelastometry parameters.

RESULTS

Fifty-six cases (mean age, 64±15 years; male/female, 37/19) and 56 controls (mean age, 76±11 years; male/female, 35/21) were enrolled. Cases and controls exhibited markedly hypercoagulable thromboelastometry profiles vs healthy individuals, mainly characterized by a significantly shorter propagation phase of coagulation (clot formation time) and significantly increased maximum clot firmness (<.001 for all comparisons). Patients with COVID-19 pneumonia had significantly shorter clot formation time and higher maximum clot firmness (<.01 and <.05, respectively, for all comparisons) than did controls.

CONCLUSION

Patients admitted to internal medicine wards for COVID-19 pneumonia presented a markedly prothrombotic state, which seems peculiar to COVID-19 rather than pneumonia itself.

摘要

目的

通过传统凝血检测和全血血栓弹力图检测，对入住内科病房的急性肺炎患者中2019冠状病毒病（COVID-19）阳性与COVID-19阴性患者的凝血指标进行综合评估。

患者与方法

我们纳入了2020年3月7日至4月30日期间因COVID-19相关肺炎（病例组）和非COVID-19肺炎（对照组）入住帕多瓦大学医院内科病房的所有连续患者。一组健康个体作为血栓弹力图参数的基线。

结果

纳入56例病例（平均年龄64±15岁；男/女，37/19）和56例对照（平均年龄76±11岁；男/女，35/21）。与健康个体相比，病例组和对照组均表现出明显的高凝血栓弹力图特征，主要表现为凝血传播期（凝块形成时间）显著缩短，最大凝块硬度显著增加（所有比较P<0.001）。COVID-19肺炎患者的凝块形成时间显著短于对照组，最大凝块硬度显著高于对照组（所有比较分别为P<0.01和P<0.05）。

结论

因COVID-19肺炎入住内科病房的患者呈现出明显的血栓前状态，这似乎是COVID-19特有的，而非肺炎本身所致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb42/7749260/fa8c8235e9b9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb42/7749260/2e092296cf37/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb42/7749260/d1d5e3f221ba/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb42/7749260/fa8c8235e9b9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb42/7749260/2e092296cf37/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb42/7749260/d1d5e3f221ba/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb42/7749260/fa8c8235e9b9/gr3.jpg

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