Emergency Department and Critical Care Area, Anesthesia and Intensive Care Unit, Santa Maria Annunziata Hospital, Bagno a Ripoli, Florence, Italy.
Department of Anesthesia and Intensive Care, Orthopedic Anesthesia, University-Hospital Careggi, Largo Palagi, 1, 50139, Florence, Italy.
J Clin Monit Comput. 2022 Feb;36(1):55-69. doi: 10.1007/s10877-021-00744-7. Epub 2021 Jul 15.
Abnormal coagulation parameters are often observed in patients with coronavirus disease 2019 (COVID-19) and the severity of derangement has been associated with a poor prognosis. The COVID-19 associated coagulopathy (CAC) displays unique features that include a high risk of developing thromboembolic complications. Viscoelastic tests (VETs), such as thromboelastometry (ROTEM), thromboelastography (TEG) and Quantra Hemostasis Analyzer (Quantra), provide "dynamic" data on clot formation and dissolution; they are used in different critical care settings, both in hemorrhagic and in thrombotic conditions. In patients with severe COVID-19 infection VETs can supply to clinicians more information about the CAC, identifying the presence of hypercoagulable and hypofibrinolysis states. In the last year, many studies have proposed to explain the underlying characteristics of CAC; however, there remain many unanswered questions. We tried to address some of the important queries about CAC through VETs analysis.
异常的凝血参数在 2019 年冠状病毒病（COVID-19）患者中经常观察到，其紊乱的严重程度与预后不良有关。COVID-19 相关的凝血障碍（CAC）具有独特的特征，包括发生血栓栓塞并发症的高风险。粘弹性测试（VET），如血栓弹力描记术（ROTEM）、血栓弹力图（TEG）和 Quantra 止血分析仪（Quantra），提供关于血栓形成和溶解的“动态”数据；它们用于不同的重症监护环境中，包括出血和血栓形成的情况。在严重 COVID-19 感染的患者中，VET 可以为临床医生提供更多关于 CAC 的信息，确定是否存在高凝和低纤维蛋白溶解状态。在过去的一年中，许多研究提出了解释 CAC 潜在特征的方法；然而，仍有许多问题没有答案。我们试图通过 VETs 分析来解决 CAC 的一些重要问题。
