Department of Internal Medicine, Faculty of Medicine, Naresuan University, Thailand.
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Thailand.
Clin Exp Rheumatol. 2021 Sep-Oct;39(5):1003-1010. doi: 10.55563/clinexprheumatol/gd9nia. Epub 2020 Oct 1.
The effect of coffee on serum uric acid (SUA) has shown conflicting results. This study was to determine the effects of caffeinated coffee (CC) and decaffeinated coffee (DC) on SUA, serum xanthine oxidase activity (sXOA) and urine uric acid clearance (UAC).
This was a prospective randomised within-subject experimental study design of 51 healthy male participants. Each study period consisted of 3 periods, including a control, an intervention, and washout period for 1, 3 and 1 week, respectively. During the intervention period, the participants received 2, 4 or 6 gram/day of coffee, either CC or DC.
For DC groups, SUA significantly decreased by 6.5 (±1.1) mg/dL to 6.2 (±1.1) mg/dL during the intervention period (p=0.014). sXOA significantly increased by 0.05 (±0.07) nmol/min/mL to 0.20 (±0.38) nmol/min/mL during the intervention period (p=0.010) of CC. For UAC, there was no significant change with CC or DC. In hyperuricaemic participants, SUA significantly decreased by 7.7 (±0.7) mg/dL to 7.2 (±0.7) mg/dL during the intervention period (p=0.028) of DC. For non-hyperuricaemic, CC significantly increased SUA by 5.9 (±0.7) mg/dL to 6.2 (±0.9) mg/dL during the intervention period (p=0.008) and significantly decreased SUA to 6.0 (±0.8) mg/dL (p=0.049) during the withdrawal period. A significant increase of sXOA according with SUA in CC groups from 0.05 (±0.07) nmol/min/mL to 0.25 (±0.44) nmol/min/mL during the intervention period (p=0.040) was presented in non-hyperuricaemic participants.
DC had a significant decrease of SUA during the intervention period. However, in non-HUS participants, SUA significantly increased in CC.
咖啡对血清尿酸（SUA）的影响结果不一。本研究旨在确定含咖啡因咖啡（CC）和脱咖啡因咖啡（DC）对 SUA、血清黄嘌呤氧化酶活性（sXOA）和尿尿酸清除率（UAC）的影响。
这是一项 51 名健康男性参与者的前瞻性随机自身对照实验研究设计。每个研究期包括对照期、干预期和洗脱期，分别为 1、3 和 1 周。在干预期间，参与者每天接受 2、4 或 6 克咖啡，CC 或 DC。
对于 DC 组，在干预期间，SUA 显著下降 6.5（±1.1）mg/dL 至 6.2（±1.1）mg/dL（p=0.014）。sXOA 在干预期间显著增加 0.05（±0.07）nmol/min/mL 至 0.20（±0.38）nmol/min/mL（p=0.010）CC。对于 UAC，CC 或 DC 均无明显变化。在高尿酸血症患者中，在干预期间，SUA 显著下降 7.7（±0.7）mg/dL 至 7.2（±0.7）mg/dL（p=0.028）DC。对于非高尿酸血症患者，CC 在干预期间使 SUA 显著增加 5.9（±0.7）mg/dL 至 6.2（±0.9）mg/dL（p=0.008），并在洗脱期间使 SUA 显著下降至 6.0（±0.8）mg/dL（p=0.049）。CC 组中，sXOA 与 SUA 呈正相关，在干预期间从 0.05（±0.07）nmol/min/mL 增加到 0.25（±0.44）nmol/min/mL（p=0.040），这在非高尿酸血症患者中表现明显。
DC 在干预期间使 SUA 显著下降。然而，在非 HUS 参与者中，CC 使 SUA 显著增加。
