线粒体外排以保护心脏：巨噬细胞的关联。
Mitochondrial Ejection for Cardiac Protection: The Macrophage Connection.
机构信息
Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, 80336 Munich, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany; Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, Neuherberg, Germany; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, 80336 Munich, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229HX Maastricht, the Netherlands; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.
出版信息
Cell Metab. 2020 Oct 6;32(4):512-513. doi: 10.1016/j.cmet.2020.09.014.
Mitochondrial dysfunction is a hallmark of heart disease. Nicolás-Ávila et al. (2020) now find that cardiomyocytes eject dysfunctional mitochondria in exopher vesicles, which require elimination by specialized heart-resident macrophages, altogether supporting proper heart function.
线粒体功能障碍是心脏病的一个标志。Nicolás-Ávila 等人（2020 年）现在发现，心肌细胞通过细胞外体囊泡排出功能失调的线粒体，这些线粒体需要专门的心脏驻留巨噬细胞来清除，这共同支持了心脏的正常功能。
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