School of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, People's Republic of China.
Hunan Key Laboratory of Colleges and Universities of Intelligent TCM Diagnosis and Preventive Treatment of Chronic Diseases, Hunan University of Chinese Medicine, Changsha, 410208, People's Republic of China.
Drug Des Devel Ther. 2024 Nov 5;18:4927-4942. doi: 10.2147/DDDT.S486816. eCollection 2024.
Heart failure (HF) is a disease with high morbidity and mortality rates worldwide and significantly affects human health. Currently, the treatment options for HF are limited, and there is an urgent need to discover new therapeutic targets and strategies. Macrophages are innate immune cells involved in the development of HF. They play a crucial role in maintaining cardiac homeostasis and regulating cardiac stress. Recently, macrophages have received increasing attention as potential targets for treating HF. With the improvement of technological means, the study of macrophages in HF has made great progress. This article discusses the biological functions of macrophage phagocytosis, immune response, and tissue repair. The polarization, pyroptosis, autophagy, and apoptosis are of macrophages, deeply involved in the pathogenesis of HF. Modulation of the phenotypic changes of macrophages can improve immune-inflammation, myocardial fibrosis, energy metabolism, apoptosis, and angiogenesis in HF.
心力衰竭（HF）是一种全球范围内发病率和死亡率都很高的疾病，严重影响人类健康。目前，HF 的治疗选择有限，迫切需要发现新的治疗靶点和策略。巨噬细胞是参与 HF 发生发展的固有免疫细胞。它们在维持心脏内稳态和调节心脏应激方面发挥着关键作用。最近，巨噬细胞作为治疗 HF 的潜在靶点受到了越来越多的关注。随着技术手段的提高，巨噬细胞在 HF 中的研究取得了很大进展。本文讨论了巨噬细胞吞噬、免疫应答和组织修复的生物学功能。巨噬细胞的极化、细胞焦亡、自噬和凋亡与 HF 的发病机制密切相关。调节巨噬细胞的表型变化可以改善 HF 中的免疫炎症、心肌纤维化、能量代谢、细胞凋亡和血管生成。
