Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Division of Regenerative Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan.
BMJ Open Diabetes Res Care. 2020 Oct;8(1). doi: 10.1136/bmjdrc-2020-001610.
Diabetes mellitus is associated with endothelial dysfunction. However, there is little information on the relationships of fasting blood glucose (FBG), including high normal blood glucose and impaired fasting glucose (IFG) with endothelial function. The purpose of this study was to evaluate the relationship between FBG level and flow-mediated vasodilation (FMD) using a large sample size.
This study was a cross-sectional study. We measured FMD in 7265 subjects at 31 general hospitals. The subjects were divided into four groups based on FBG levels: <100, 100-109, 110-125, and ≥126 mg/dL or known diabetes. The subjects were also divided into six groups based on FBG levels: <90, 90-94, 95-99, 100-109, 110-125, and ≥126 mg/dL or known diabetes.
FMD decreased in relation to increase in FBG level. There was a significant difference in FMD between the FBG of <100 mg/dL group and the other three groups (6.7±3.1% vs 5.9±2.8%, 5.7±3.1%, and 5.1±2.6%, respectively; p<0.001). After adjustment for confounding factors, the odds of having the lowest quartile of FMD were significantly higher in the FBG of 95-99, 100-104, 105-109, 110-125, and ≥126 mg/dL or known diabetes groups than in the FBG of the <90 mg/dL group.
These findings suggest that FBG of 100-109 mg/dL and FBG of 110-125 mg/dL are similarly associated with endothelial dysfunction and that a pre-IFG state (FBG of 95-99 mg/dL) is also a risk for endothelial dysfunction compared with FBG of <90 mg/dL.
UMIN000012950, UMIN000012951, UMIN000012952, and UMIN000003409.
糖尿病与血管内皮功能障碍有关。然而，有关空腹血糖（FBG）的信息（包括正常高值血糖和空腹血糖受损）与内皮功能的关系甚少。本研究的目的是使用大样本量评估 FBG 水平与血流介导的血管扩张（FMD）之间的关系。
这是一项横断面研究。我们在 31 家综合医院测量了 7265 名受试者的 FMD。根据 FBG 水平将受试者分为四组：<100、100-109、110-125 和≥126mg/dL 或已知糖尿病。根据 FBG 水平，受试者还分为六组：<90、90-94、95-99、100-109、110-125 和≥126mg/dL 或已知糖尿病。
随着 FBG 水平的升高，FMD 呈下降趋势。FBG<100mg/dL 组与其他三组之间的 FMD 差异有统计学意义（6.7±3.1%比 5.9±2.8%、5.7±3.1%和 5.1±2.6%；p<0.001）。调整混杂因素后，FBG 在 95-99、100-104、105-109、110-125 和≥126mg/dL 或已知糖尿病组中处于最低四分位数的可能性明显高于 FBG<90mg/dL 组。
这些发现表明，FBG 为 100-109mg/dL 和 FBG 为 110-125mg/dL 与内皮功能障碍同样相关，而 IFG 前期（FBG 为 95-99mg/dL）与 FBG<90mg/dL 相比也是内皮功能障碍的一个危险因素。
UMIN000012950、UMIN000012951、UMIN000012952 和 UMIN000003409。
