翅膀 imaginal 盘产生的刺猬诱导三个靶组织产生明显的反应。
Hedgehog produced by the wing imaginal disc induces distinct responses in three target tissues.
机构信息
Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA.
Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
出版信息
Development. 2020 Nov 17;147(22):dev195974. doi: 10.1242/dev.195974.
Hedgehog (Hh) is an evolutionarily conserved signaling protein that has essential roles in animal development and homeostasis. We investigated Hh signaling in the region of the wing imaginal disc that produces Hh and is near the tracheal air sac primordium (ASP) and myoblasts. Hh distributes in concentration gradients in the anterior compartment of the wing disc, ASP and myoblasts, and activates genes in each tissue. Some targets of Hh signal transduction are common to the disc, ASP and myoblasts, whereas others are tissue-specific. Signaling in the three tissues is cytoneme-mediated and cytoneme-dependent. Some ASP cells project cytonemes that receive both Hh and Branchless (Bnl), and some targets regulated by Hh signaling in the ASP are also dependent on Bnl signal transduction. We conclude that the single source of Hh in the wing disc regulates cell type-specific responses in three discreet target tissues.
刺猬（Hh）是一种进化上保守的信号蛋白，在动物发育和内稳态中具有重要作用。我们研究了产生 Hh 的翅膀图像盘区域中的 Hh 信号，该区域靠近气管气囊原基（ASP）和肌肉母细胞。Hh 在翅膀盘、ASP 和肌肉母细胞的前室中呈浓度梯度分布，并激活每个组织中的基因。Hh 信号转导的一些靶标在盘、ASP 和肌肉母细胞中是共同的，而另一些则是组织特异性的。三种组织中的信号传导是由纤毛介导和依赖纤毛的。一些 ASP 细胞伸出纤毛，接收 Hh 和分支less（Bnl），而 Hh 信号在 ASP 中调节的一些靶标也依赖于 Bnl 信号转导。我们得出的结论是，翅膀盘中单一的 Hh 来源调节三个离散靶组织中细胞类型特异性的反应。
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