Fisher D A
Pediatr Clin North Am. 1987 Aug;34(4):881-90. doi: 10.1016/s0031-3955(16)36292-7.
The author reviews the background information and technical developments leading to newborn screening for congenital hypothyroidism as well as the effectiveness and problems of the programs during the past decade. The success of the programs in terms of prevention of mental retardation now is clear. It is also clear, however, that a significant number of affected infants, perhaps 8 to 10 per cent of the total, can be missed in the best of screening programs. Physicians must be aware of the possibility and alert to early clinical evidence of congenital hypothyroidism.
作者回顾了导致先天性甲状腺功能减退症新生儿筛查的背景信息和技术发展，以及过去十年中这些项目的有效性和问题。目前，这些项目在预防智力迟钝方面的成功是显而易见的。然而，同样明显的是，在最好的筛查项目中，仍有相当数量（可能占总数的8%至10%）的患病婴儿会被漏诊。医生必须意识到这种可能性，并对先天性甲状腺功能减退症的早期临床证据保持警惕。
