他克莫司治疗眼眶及头颅型特发性炎性假瘤
Tacrolimus for Treating Orbital and Cranial Form of Idiopathic Inflammatory Pseudotumors.
作者信息
Kim Hyun Jae, Lee Seonkyung, Koo Yu Jin, Kwon Eunjin, Kim Hyo Jung, Choi Jeong Yoon, Kim Ji Soo
机构信息
Dizziness Center, Clinical Neuroscience Center, Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea.
Department of Medical Sciences, Neurology, Graduate School of Ajou University, Suwon, Korea.
出版信息
J Clin Neurol. 2020 Oct;16(4):674-680. doi: 10.3988/jcn.2020.16.4.674.
BACKGROUND AND PURPOSE
Orbital and cranial form of idiopathic inflammatory pseudotumors (IIPs) are rare disorders with heterogeneous clinical presentations. Corticosteroids have been the first-line treatment for IIPs, but they are not always effective.
METHODS
We reviewed the medical records of three patients with orbital or cranial form of IIP who were treated with tacrolimus as an adjuvant treatment.
RESULTS
The three patients showed favorable outcomes with the addition of tacrolimus, which is a calcineurin inhibitor that inhibits T-cell activation and T-cell-dependent B-cell activation.
CONCLUSIONS
Tacrolimus may be a safe and effective immunosuppressant for refractory or relapsing form of orbital or cranial IIPs.
背景与目的
特发性炎性假瘤（IIP）的眼眶型和颅型是临床症状各异的罕见疾病。皮质类固醇一直是IIP的一线治疗药物，但并非总是有效。
方法
我们回顾了3例眼眶型或颅型IIP患者接受他克莫司辅助治疗的病历。
结果
这3例患者加用他克莫司后均取得了良好疗效，他克莫司是一种钙调神经磷酸酶抑制剂，可抑制T细胞活化及T细胞依赖性B细胞活化。
结论
对于难治性或复发性眼眶型或颅型IIP，他克莫司可能是一种安全有效的免疫抑制剂。
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