N-去二甲基-N-丙酰基-6,9;9,12-红霉素A-螺缩酮，琥乙红霉素在人体内的一种新代谢产物。
N-Didemethyl-n-propionyl-6,9;9, 12-erythromycin A-spiroketal, a new metabolite of erythromycin ethyl succinate in man.
作者信息
Majer J, Stanaszek R S, Mueller S L, Marti G
出版信息
Drug Metab Dispos. 1978 Nov-Dec;6(6):673-6.
PMID:33030
Abstract
A novel, neutral metabolite of erythromycin was isolated from the urine of a patient treated with erythromycin ethyl succinate. After separation and purification on Sephadex LH-20 column chromatography, the structure of the metabolite was deduced from spectral data to be the propionamide of the didemethylated 6,9;9, 12-spiroketal of erythromycin A.
摘要
从一名接受琥乙红霉素治疗的患者尿液中分离出一种新型的红霉素中性代谢物。经葡聚糖凝胶LH - 20柱色谱分离纯化后，根据光谱数据推断该代谢物的结构为红霉素A的6,9;9,12 - 螺缩酮二去甲基化产物的丙酰胺。
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