其代谢产物对红霉素体外耐药性的诱导
In vitro induction of resistance to erythromycin by its metabolite.
作者信息
Majer J
出版信息
Antimicrob Agents Chemother. 1981 Apr;19(4):628-33. doi: 10.1128/AAC.19.4.628.
Abstract
Of the metabolites isolated from urine samples of patients treated with erythromycin, the 8,9-anhydroerythromycin A 6,9-hemiketal induced in vitro resistance to the parent drug and to carbomycin in the test strain Staphylococcus aureus RN 1389.
摘要
在从接受红霉素治疗的患者尿液样本中分离出的代谢产物中，8,9-脱水红霉素A 6,9-半缩酮在测试菌株金黄色葡萄球菌RN 1389中诱导了对母体药物和碳霉素的体外抗性。
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