[大鼠尿液中5-乙基-2'-脱氧尿苷代谢产物的分离与鉴定]
[Isolation and identification of metabolites of 5-ethyl-2'-deoxyuridine from rat urine].
作者信息
Kaul R, Hempel B
出版信息
Arzneimittelforschung. 1985;35(7):1055-7.
PMID:4052140
Abstract
The metabolites of 5-ethyl-2'-deoxyuridine (Aedurid) have been isolated and purified from rat urine by preparative thin-layer and column chromatography. With the aid of 1H-NMR and mass spectroscopy and by comparison with an authentic sample, the major metabolite could be identified as 5-(1-hydroxyethyl)uracil. The minor metabolite was identified as 5-ethyluracil.
摘要
5-乙基-2'-脱氧尿苷（阿多尿苷）的代谢产物已通过制备型薄层色谱法和柱色谱法从大鼠尿液中分离并纯化出来。借助氢核磁共振波谱和质谱，并与标准样品进行比较，主要代谢产物可鉴定为5-(1-羟乙基)尿嘧啶。次要代谢产物鉴定为5-乙基尿嘧啶。
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