Cloyd Jordan M, Hyman Sarah, Huwig Tanya, Monsour Christina, Santry Heena, Wills Celia, Tsung Allan, Bridges John F P
Department of Surgery, College of Medicine, The Ohio State Wexner Medical Center, Columbus, OH, USA.
Division of Surgical Oncology, The Ohio State University Wexner Medical Center, 410 W 10th Ave, N-907 Doan Hall, Columbus, OH, 43210, USA.
Support Care Cancer. 2021 Jun;29(6):3009-3016. doi: 10.1007/s00520-020-05813-2. Epub 2020 Oct 8.
Neoadjuvant therapy (NT) is increasingly being offered to patients with pancreatic ductal adenocarcinoma (PDAC) prior to surgical resection. However, the experience and quality of life (QOL) of patients undergoing NT are poorly understood.
A systematic review of the Cinahl, Embase, Medline, Pubmed, Scopus, and Web of Science databases was conducted to evaluate the available literature pertaining to the experience and QOL of patient's undergoing NT for PDAC.
Among 6041 articles screened, only six met criteria for full-text review including three prospective clinical trials of NT with QOL secondary endpoints. Overall, global QOL during or following NT did not significantly change from baseline. Pain scores seemed to improve during NT while the impact of NT on physical functioning varied across studies. No studies were identified evaluating other aspects of the patient experience.
Although NT appears to have a minor impact on the QOL of patients with PDAC, this systematic review identified significant evidence gaps in the literature. A protocol of a prospective observational cohort study utilizing a digital smartphone app that aims to evaluate the patient experience and longitudinal QOL of patients with PDAC undergoing NT is presented.
新辅助治疗（NT）越来越多地应用于胰腺导管腺癌（PDAC）患者手术切除前。然而，接受NT治疗患者的经历和生活质量（QOL）仍知之甚少。
对CINAHL、Embase、Medline、Pubmed、Scopus和Web of Science数据库进行系统综述，以评估有关接受PDAC的NT治疗患者的经历和QOL的现有文献。
在筛选的6041篇文章中，只有6篇符合全文审查标准，其中包括3项以QOL为次要终点的NT前瞻性临床试验。总体而言，NT期间或之后的总体QOL与基线相比没有显著变化。NT期间疼痛评分似乎有所改善，而NT对身体功能的影响在不同研究中有所不同。未发现评估患者经历其他方面的研究。
尽管NT似乎对PDAC患者的QOL影响较小，但该系统综述发现文献中存在明显的证据空白。本文介绍了一项前瞻性观察队列研究方案，该方案利用数字智能手机应用程序，旨在评估接受NT治疗的PDAC患者的经历和纵向QOL。
