van Dijk Sven M, Heerkens Hanne D, Tseng Dorine S J, Intven Martijn, Molenaar I Quintus, van Santvoort Hjalmar C
Department of Research and Development, St. Antonius Hospital, Nieuwegein, The Netherlands.
Department of Radiotherapy, University Medical Center, Utrecht, The Netherlands.
HPB (Oxford). 2018 Mar;20(3):204-215. doi: 10.1016/j.hpb.2017.11.002. Epub 2017 Dec 15.
Patients undergoing pancreatoduodenectomy for pancreatic cancer have a high risk of major postoperative complications and a low survival rate. Insight in the impact of pancreatoduodenectomy on quality of life (QoL) is therefore of great importance. The aim of this systematic review was to assess QoL after pancreatoduodenectomy for pancreatic cancer.
A systematic review of the literature was performed according to the PRISMA guidelines. A systematic search of all the English literature available in PubMed and Medline was performed. All studies assessing QoL with validated questionnaires in pancreatic cancer patients undergoing pancreatoduodenectomy were included.
After screening a total of 788 articles, the full texts of 36 articles were assessed, and 17 articles were included. QoL of physical and social functioning domains decreased in the first 3 months after surgery. Recovery of physical and social functioning towards baseline values took place after 3-6 months. Pain, fatigue and diarrhoea scores deteriorated postoperatively, but eventually resolved after 3-6 months.
Pancreatoduodenectomy for malignant disease negatively influences QoL in the physical and social domains at short term. It will eventually recover to baseline values after 3-6 months. This information is valuable for counselling and expectation management of patients undergoing pancreatoduodenectomy.
因胰腺癌接受胰十二指肠切除术的患者术后发生严重并发症的风险较高，生存率较低。因此，了解胰十二指肠切除术对生活质量（QoL）的影响至关重要。本系统评价的目的是评估胰腺癌患者接受胰十二指肠切除术后的生活质量。
根据PRISMA指南对文献进行系统评价。对PubMed和Medline中所有可用的英文文献进行系统检索。纳入所有使用经过验证的问卷评估接受胰十二指肠切除术的胰腺癌患者生活质量的研究。
在总共筛选了788篇文章后，对36篇文章的全文进行了评估，纳入了17篇文章。身体和社会功能领域的生活质量在术后前3个月下降。身体和社会功能在3 - 6个月后恢复到基线值。疼痛、疲劳和腹泻评分术后恶化，但最终在3 - 6个月后缓解。
恶性疾病的胰十二指肠切除术在短期内对身体和社会领域的生活质量有负面影响。最终在3 - 6个月后将恢复到基线值。该信息对于接受胰十二指肠切除术患者的咨询和预期管理具有重要价值。
