Thiels C
Pharmacopsychiatry. 1987 Jul;20(4):133-46. doi: 10.1055/s-2007-1017092.
The literature in most European languages was consulted for guidelines regarding the drug treatment of psychiatrically disturbed pregnant or lactating women. The available information allows only a few conclusions. Lithium exposure during the first trimester seems to increase the risk of congenital heart disease, especially Ebstein's anomaly. As there is still insufficient evidence to prove the safeness of other psychoactive drugs for the fetus, caution seems warranted here too. A causal link between pharmacotherapy of the mother-to-be and malformation of the baby is difficult to prove. But toxic and withdrawal symptoms in infants born to women treated regularly until shortly before confinement are well documented for most psychoactive drugs.
查阅了大多数欧洲语言的文献，以获取有关精神错乱的孕妇或哺乳期妇女药物治疗的指南。现有信息仅能得出一些结论。孕早期接触锂似乎会增加先天性心脏病的风险，尤其是埃布斯坦畸形。由于仍没有足够的证据证明其他精神活性药物对胎儿是安全的，在此也似乎有必要谨慎使用。很难证明准妈妈的药物治疗与婴儿畸形之间存在因果关系。但对于大多数精神活性药物来说，在分娩前不久仍接受定期治疗的妇女所生婴儿出现中毒和戒断症状的情况已有充分记录。
