DuPont H L, Sullivan P, Pickering L K, Haynes G, Ackerman P B
Gastroenterology. 1977 Oct;73(4 Pt 1):715-8.
Students attending a Mexican university who developed diarrhea were randomly treated with bismuth subsalicylate or a placebo. One hundred and eleven were given 30 ml each 1/2 hr until eight doses (total dose of active drug 4.2 g) were given and 58 students received twice this dose (8.2 g of active drug) over the 3 1/2-hr treatment period. The number of unformed stools was significantly decreased in both bismuth subsalicylate treatment groups compared to the placebo controls for the period 4 to 24 hr after therapy. A reduction in diarrhea was additionally noted for the duration of the 48-hr surveillance period for the students receiving the higher dose of active drug. Subjective relief within 24 hr of therapy of the symptoms of diarrhea, nausea, and abdominal pain or cramps was reported with a significantly increased frequency in the bismuth subsalicylate group. The most pronounced effect of the treatment occurred in the United States students with diarrhea who had recently arrived in Mexico. This appeared to be related to the favorable effect of bismut subsalicylate on the course of toxigenic Escherichia coli infection. Students with shigellosis did not experience a prolonged illness in either treatment group.
就读于墨西哥一所大学且出现腹泻症状的学生被随机给予碱式水杨酸铋或安慰剂进行治疗。111名学生每半小时服用30毫升，直至服用八剂（活性药物总剂量4.2克），58名学生在3个半小时的治疗期内服用两倍剂量（8.2克活性药物）。与安慰剂对照组相比，在治疗后4至24小时期间，两个碱式水杨酸铋治疗组的不成形粪便数量均显著减少。对于接受较高剂量活性药物的学生，在48小时监测期内腹泻情况也有所减轻。碱式水杨酸铋组报告在治疗24小时内腹泻、恶心以及腹痛或痉挛症状主观缓解的频率显著增加。治疗效果最显著的是刚抵达墨西哥且患有腹泻的美国学生。这似乎与碱式水杨酸铋对产毒性大肠杆菌感染病程的有利影响有关。在两个治疗组中，患志贺氏菌病的学生病程均未延长。
