冠状动脉侧支微循环储备随年龄增长而退化。
Coronary Collateral Microcirculation Reserve Becomes Vestigial with Aging.
机构信息
Department of Thoracic Cardiovascular Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Morphological Research Experiment Center, Xuzhou Medical University, Xuzhou, China.
出版信息
Cardiology. 2021;146(1):11-18. doi: 10.1159/000509915. Epub 2020 Oct 8.
INTRODUCTION
Our previous study indicated that coronary collateral microcirculation reserve (CCMR), native collaterals, transports blood flow to an ischemic area to reduce ischemic tissue injury. This study aimed to observe the changes of CCMR in the hearts of different month-old rats.
METHODS
We selected 2-, 8-, 16-, and 24-month-old rats as the research objects to monitor the changes of CCMR in rats with aging. After acute myocardial infarction, lectin-FITC was injected into the femoral vein vessels of rats to mark CCMR vessels in the ischemic area.
RESULTS
Results of the lectin-FITC perfusion experiment indicated that the number and collagen IV coverage of CCMR vessels declined with aging. Moreover, data suggested a correlation between endothelial nitric oxide synthase and a decline in the number of CCMR vessels.
CONCLUSION
Aging causes CCMR decline in rats.
简介
我们之前的研究表明，冠状动脉侧支微循环储备（CCMR），即内源性侧支，将血液输送到缺血区域，以减少缺血组织损伤。本研究旨在观察不同月龄大鼠心脏中 CCMR 的变化。
方法
我们选择 2 个月、8 个月、16 个月和 24 个月大的大鼠作为研究对象，监测大鼠衰老过程中 CCMR 的变化。急性心肌梗死后，将凝集素-FITC 注入大鼠股静脉血管，标记缺血区的 CCMR 血管。
结果
凝集素-FITC 灌注实验结果表明，CCMR 血管的数量和胶原 IV 覆盖率随年龄增长而下降。此外，数据表明内皮型一氧化氮合酶与 CCMR 血管数量的减少之间存在相关性。
结论
衰老导致大鼠 CCMR 下降。
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