肥胖与哮喘。

Obesity and asthma.

机构信息

Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University of Marburg, Marburg, Germany.

Department of Clinical Immunology and Allergology, Laboratory of Immunopathology, Sechenov University, Moscow, Russia.

出版信息

J Allergy Clin Immunol. 2020 Oct;146(4):685-693. doi: 10.1016/j.jaci.2020.08.011.

DOI:10.1016/j.jaci.2020.08.011

PMID:33032723

Abstract

Obesity has been well recognized as an important comorbidity in patients with asthma, representing a unique phenotype and endotype. This association indicates a close relationship between metabolic and inflammatory dysregulation. However, the detailed organ-organ, cellular, and molecular interactions are not completely resolved. Because of that, the relationship between obesity and asthma remains unclear. In this article, clinical and epidemiological studies, as well as data from experimental animal work, are being summarized to provide a state of the art update on this important topic. Much more work is needed, particularly mechanistic, to fully understand the interaction between obesity and asthma and to develop novel preventive and therapeutic strategies.

摘要

肥胖症已被充分确认为哮喘患者的一种重要合并症，代表了一种独特的表型和内型。这种关联表明代谢和炎症失调之间存在密切关系。然而，详细的器官-器官、细胞和分子相互作用尚未完全解决。因此，肥胖症和哮喘之间的关系仍不清楚。在本文中，对临床和流行病学研究以及实验动物工作的数据进行了总结，为这一重要主题提供了最新的研究进展。还需要开展更多的工作，特别是在机制方面，以充分了解肥胖症和哮喘之间的相互作用，并开发新的预防和治疗策略。