Bielefeld University, International Research Training Group "Computational Methods for the Analysis of the Diversity and Dynamics of Genomes" and Genome Informatics, Faculty of Technology and Center for Biotechnology, Bielefeld, Germany.
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia.
Sci Rep. 2019 Nov 8;9(1):16302. doi: 10.1038/s41598-019-52762-w.
Asthma and hypertension are complex diseases coinciding more frequently than expected by chance. Unraveling the mechanisms of comorbidity of asthma and hypertension is necessary for choosing the most appropriate treatment plan for patients with this comorbidity. Since both diseases have a strong genetic component in this article we aimed to find and study genes simultaneously associated with asthma and hypertension. We identified 330 shared genes and found that they form six modules on the interaction network. A strong overlap between genes associated with asthma and hypertension was found on the level of eQTL regulated genes and between targets of drugs relevant for asthma and hypertension. This suggests that the phenomenon of comorbidity of asthma and hypertension may be explained by altered genetic regulation or result from drug side effects. In this work we also demonstrate that not only drug indications but also contraindications provide an important source of molecular evidence helpful to uncover disease mechanisms. These findings give a clue to the possible mechanisms of comorbidity and highlight the direction for future research.
哮喘和高血压是两种复杂的疾病，它们同时发生的频率高于预期的偶然情况。为了为患有这种合并症的患者选择最合适的治疗方案，阐明哮喘和高血压合并症的机制是必要的。由于这两种疾病在遗传成分上都很强，我们的目标是在本文中找到并研究同时与哮喘和高血压相关的基因。我们确定了 330 个共享基因，并发现它们在相互作用网络上形成了六个模块。在受调控基因的 eQTL 水平和与哮喘和高血压相关药物的靶点之间，发现与哮喘和高血压相关的基因之间存在很强的重叠。这表明哮喘和高血压合并症的现象可能是由遗传调控改变或药物副作用引起的。在这项工作中，我们还证明，不仅药物适应证，而且禁忌证也为揭示疾病机制提供了重要的分子证据来源。这些发现为合并症的可能机制提供了线索，并为未来的研究指明了方向。
