Aärimaa M
Scand J Gastroenterol Suppl. 1987;127:81-5.
The risk of recurrent duodenal ulcer is high, 70-80% of duodenal ulcer patients having a recurrence during the first year after initial healing. Surgery has so far been the main method for preventing a relapse, but recent studies have shown that it is possible to reduce the risk and the need for surgery with medical maintenance therapy. Five controlled studies are available on the efficacy of sucralfate in prophylaxis for duodenal ulcer. 294 patients participated, 154 having received sucralfate treatment, usually 1 g twice daily. The summarized results indicate that initially healed duodenal ulcers recurred in six months in 60% of cases and in 12 months in 79% of cases in groups receiving placebo therapy or no treatment, the corresponding figures in the groups treated with sucralfate being 21% and 31%. The choice between surgical and medical prophylaxis is discussed, and more liberal use of medical prophylaxis is advocated.
十二指肠溃疡复发的风险很高，70%-80%的十二指肠溃疡患者在初次愈合后的第一年就会复发。到目前为止，手术一直是预防复发的主要方法，但最近的研究表明，通过药物维持治疗可以降低复发风险并减少手术需求。关于硫糖铝预防十二指肠溃疡疗效的对照研究有五项。294名患者参与其中，154名接受了硫糖铝治疗，通常为每日两次，每次1克。总结结果表明，接受安慰剂治疗或未接受治疗的组中，初愈的十二指肠溃疡在6个月时复发率为60%，在12个月时为79%，而接受硫糖铝治疗的组中相应数字分别为21%和31%。文中讨论了手术预防和药物预防之间的选择，并提倡更广泛地使用药物预防。
