Pop P, Nikkels R E, Thys O, Dorrestein G C
Scand J Gastroenterol Suppl. 1983;83:43-7.
Sixty-three outpatients with endoscopically proven duodenal ulcer and 58 with gastric ulcer were treated under single-blind conditions with either sucralfate, 4 g daily, or with cimetidine, 1 g daily. Endoscopy was performed after 4 weeks and again after 6 weeks if the ulcer had not healed. Among the duodenal ulcer patients, 22 of 31 (71.0%) who received sucralfate and 24 of 32 (75.0%) who received cimetidine were healed after 4 weeks. After 6 weeks, the overall healing rate was 96.8% in the sucralfate group and 96.9% in the cimetidine group. Of 28 gastric ulcer patients who received sucralfate, 10 (35.7%) were healed after 4 weeks, compared with 18 of 30 (60.0%) who received cimetidine. The overall healing rates after 6 weeks were 71.4% in the sucralfate group and 83.3% in the cimetidine group. None of the differences between treatment groups was statistically significant. No serious side effects occurred with either drug. The results suggest that sucralfate and cimetidine are equally effective in the short-term treatment of peptic ulcer.
63例经内镜证实为十二指肠溃疡的门诊患者和58例胃溃疡患者在单盲条件下接受治疗，分别给予硫糖铝每日4克或西咪替丁每日1克。4周后进行内镜检查，如果溃疡未愈合，则在6周后再次进行内镜检查。在十二指肠溃疡患者中，接受硫糖铝治疗的31例中有22例（71.0%）在4周后愈合，接受西咪替丁治疗的32例中有24例（75.0%）在4周后愈合。6周后，硫糖铝组的总体愈合率为96.8%，西咪替丁组为96.9%。在接受硫糖铝治疗的28例胃溃疡患者中，4周后有10例（35.7%）愈合，而接受西咪替丁治疗的30例中有18例（60.0%）愈合。6周后的总体愈合率硫糖铝组为71.4%，西咪替丁组为83.3%。各治疗组之间的差异均无统计学意义。两种药物均未出现严重副作用。结果表明，硫糖铝和西咪替丁在消化性溃疡的短期治疗中疗效相当。
