Yan Haixi, Cai Linling, Chen Shuaishuai, Li Jun
Taizhou Enze Medical Center(Group), Taizhou Hospital of Zhejiang Province, Department of Clinical Laboratory, Linhai, Zhejiang Province, China.
J Med Biochem. 2020 Jan 23;39(2):160-164. doi: 10.2478/jomb-2019-0031.
We investigated the prognostic value of the preoperative lymphocyte-to-mononuclear ratio (LMR) and platelet-to-lymphocyte ratio (PLR) in a large cohort of patients with non-small cell lung cancer (NSCLC).
Clinical-pathological data from 507 NSCLC patients at Taizhou Hospital of Zhejiang Province between 2010 and 2016 were retrospectively evaluated. X-tile software was used to assess the optimal cutoff levels for LMR and PLR. Univariate and multivariate Cox regression models were used to assess the prognostic factors.
The median follow-up duration after surgical resection was 34.5 months. Patients were stratified into 2 groups by LMR (2.6 and > 2.6) and PLR (179.6 and > 179.6). Our results revealed that lower LMR (HR = 3.163 (1.821-5.493), P = 0.000), age (HR = 2.252 (1.412-3.592), P = 0.001), T stage (HR = 3.749 (2.275-6.179), P = 0.000), N stage (HR = 3.106 (1.967-4.902), P = 0.000), and cut edge (HR = 3.830 (1.077-13.618), P = 0.038) were considered to be independent indicators for overall survival (OS) of NSCLC patients. For disease-free survival (DFS), age, sex, T stage, N stage, LMR and cut edge were verified to be independent prognostic factors in patients with NSCLC.
In the study cohort, reduced LMR was a robust independent predictor for both OS and DFS in patients with NSCLC who underwent surgical resection.
我们在一大群非小细胞肺癌（NSCLC）患者中研究了术前淋巴细胞与单核细胞比值（LMR）和血小板与淋巴细胞比值（PLR）的预后价值。
回顾性评估了2010年至2016年期间浙江省台州医院507例NSCLC患者的临床病理数据。使用X-tile软件评估LMR和PLR的最佳截断水平。采用单因素和多因素Cox回归模型评估预后因素。
手术切除后的中位随访时间为34.5个月。患者按LMR（2.6及>2.6）和PLR（179.6及>179.6）分为两组。我们的结果显示，较低的LMR（HR = 3.163（1.821 - 5.493），P = 0.000）、年龄（HR = 2.252（1.412 - 3.592），P = 0.001）、T分期（HR = 3.749（2.275 - 6.179），P = 0.000）、N分期（HR = 3.106（1.967 - 4.902），P = 0.000）和切缘（HR = 3.830（1.077 - 13.618），P = 0.038）被认为是非小细胞肺癌患者总生存期（OS）的独立指标因素。对于无病生存期（DFS），年龄、性别、T分期、N分期、LMR和切缘被证实是非小细胞肺癌患者的独立预后因素。
在该研究队列中，LMR降低是接受手术切除的非小细胞肺癌患者OS和DFS的有力独立预测指标。
