University of Michigan Medical School, Ann Arbor, MI, USA.
University of Michigan Rogel Cancer Center, 1500 E Medical Drive 7217, Ann Arbor, MI, 48109, USA.
Breast Cancer Res Treat. 2021 Jan;185(1):229-238. doi: 10.1007/s10549-020-05938-2. Epub 2020 Oct 8.
Inflammatory breast cancer (IBC) is an aggressive variant characterized by erythema, edema, and "peau d'orange" of the skin progressing within 6 months. We assessed the incidence and survival of IBC in the US over four decades.
Using SEER*Stat, a case list of IBC patients diagnosed between 1973 and 2015 (n = 29,718) was extracted from SEER 18 registries by using a combination of morphology, stage, and extent of disease criteria. M1 and M0 patients were included. Age-adjusted incidence rates, relative survival rates, and mean survival time were calculated. Significance was determined as non-overlapping 95% confidence intervals.
The overall incidence of IBC from 1973 to 2015 is 2.76 (2.73, 2.79) cases per 100,000 people, with white patients having an incidence rate of 2.63 (2.60, 2.67), black patients 4.52 (4.39, 4.65), and patients of other race 1.84 (1.76, 1.93). The overall IBC relative 5-year survival rate is 40.5% (39.0%, 42.0%), 42.5% (40.7%, 44.3%), and 29.9% (26.6%, 33.3%) for white patients and black patients, respectively. Patients diagnosed in 1978-1982 have a mean survival time of 62.3 (52.0, 72.6) months, while those diagnosed in 2008-2012 have mean survival time of 99.4 (96.4, 102.4) months. There is no significant difference in survival time between T4D patients and patients with other T staging and extent of disease coding consistent with clinical IBC presentation.
IBC survival has increased over four decades. Despite the improvement in survival for all racial groups, a persistent survival disparity that has not narrowed over two decades remains between white and black patients.
炎性乳腺癌（IBC）是一种侵袭性变体，其特征为皮肤红斑、水肿和“橘皮样变”，在 6 个月内进展。我们评估了美国在过去四十年中 IBC 的发病率和生存率。
使用 SEER*Stat，通过形态学、分期和疾病程度标准的组合，从 SEER 18 个登记处提取了 1973 年至 2015 年期间诊断为 IBC 的患者的病例列表（n=29718）。包括 M1 和 M0 患者。计算了年龄调整发病率、相对生存率和平均生存时间。非重叠 95%置信区间确定为显著性。
1973 年至 2015 年 IBC 的总体发病率为每 100000 人 2.76（2.73，2.79）例，白人患者的发病率为 2.63（2.60，2.67），黑人患者为 4.52（4.39，4.65），其他种族患者为 1.84（1.76，1.93）。IBC 的总体 5 年相对生存率为 40.5%（39.0%，42.0%）、42.5%（40.7%，44.3%）和 29.9%（26.6%，33.3%），白人患者和黑人患者分别为 42.5%（40.7%，44.3%）和 29.9%（26.6%，33.3%）。1978-1982 年诊断的患者平均生存时间为 62.3（52.0，72.6）个月，而 2008-2012 年诊断的患者平均生存时间为 99.4（96.4，102.4）个月。在 T4D 患者和其他 T 分期和疾病程度编码的患者之间，生存时间没有显著差异，这些患者的临床表现与临床 IBC 一致。
IBC 的生存率在过去四十年中有所提高。尽管所有种族群体的生存率都有所提高，但白人和黑人患者之间仍存在持续的生存差距，且在过去二十年中并未缩小。
