Department of Parasitology, Instituto de Investigación Biosanitaria (ibs.Granada), Hospitales Universitarios De Granada/University of Granada, Severo Ochoa s/n, 18071 Granada, Spain.
Department of Physical Chemistry, University of Granada, Av. Fuentenueva s/n, 18071, Granada, Spain.
ACS Infect Dis. 2020 Nov 13;6(11):2830-2843. doi: 10.1021/acsinfecdis.0c00353. Epub 2020 Oct 9.
Chagas disease is a neglected tropical disease and a global public health issue. In terms of treatment, no progress has been made since the 1960s, when benznidazole and nifurtimox, two obsolete drugs still prescribed, were used to treat this disease. Hence, currently, there are no effective treatments available to tackle Chagas disease. Over the past 20 years, there has been an increasing interest in the disease. However, parasite genetic diversity, drug resistance, tropism, and complex life cycle, along with the limited understanding of the disease and inadequate methodologies and strategies, have resulted in the absence of new insights in drugs development and disappointing outcomes in clinical trials so far. In summary, new drugs are urgently needed. This Review considers the relevant aspects related to the lack of drugs for Chagas disease, resumes the advances in tools for drug discovery, and discusses the main features to be taken into account to develop new effective drugs.
恰加斯病是一种被忽视的热带病，也是一个全球性的公共卫生问题。在治疗方面，自 20 世纪 60 年代以来，尚无进展，当时使用两种已过时的药物苯唑硝唑和硝呋替莫来治疗这种疾病。因此，目前尚无有效的方法来治疗恰加斯病。在过去的 20 年中，人们对这种疾病的兴趣日益增加。然而，寄生虫遗传多样性、药物耐药性、趋向性和复杂的生命周期，以及对疾病的有限认识以及方法和策略的不足，导致药物开发缺乏新的见解，临床试验的结果也令人失望。总之，急需新的药物。这篇综述考虑了与恰加斯病缺乏药物相关的各个方面，总结了药物发现工具的进展，并讨论了开发新的有效药物需要考虑的主要特征。
