Kuyumcu Mevlüt Serdar, Kuyumcu Aliye
Department of Cardiology, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey.
Department of Nutrition and Dietetics, Süleyman Demirel University Faculty of Health Sciences, Isparta, Turkey.
Turk Kardiyol Dern Ars. 2020 Oct;48(7):690-697. doi: 10.5543/tkda.2020.03205.
The precise pathophysiology of slow coronary flow (SCF) has not yet been clarified; however, many studies have shown that significant fructose consumption is associated with oxidative stress and inflammation, which may play a role in the pathophysiology of SCF. The aim of this study was to investigate the association between fructose consumption and isolated SCF.
Patients with stable angina pectoris who underwent coronary angiography between December 2018 and April 2019 were evaluated for this study. In all, 45 patients with isolated SCF were selected as the patient group (SCF group) and 50 patients with a normal coronary flow pattern were enrolled as a control group. Participants used a dietary record to provide details of nutrient consumption and all of the data from the 2 groups were compared.
The high-sensitivity C-reactive protein (Hs-CRP) level (p=0.024), white blood cell count (p=0.038), and smoking rate (p=0.012) were higher in the SCF group. Total energy (p=0.029), carbohydrate (p=0.047), and fructose consumption (p<0.001) were also higher in the SCF group. Multivariable logistic regression analysis demonstrated that a higher level of Hs-CRP, fructose consumption, and smoking were independently associated with SCF.
The SCF group demonstrated a higher level of fructose consumption. Excessive fructose consumption may play a role in SCF pathophysiology.
冠状动脉血流缓慢（SCF）的确切病理生理学尚未阐明；然而，许多研究表明，大量摄入果糖与氧化应激和炎症有关，这可能在SCF的病理生理学中起作用。本研究的目的是调查果糖摄入量与孤立性SCF之间的关联。
对2018年12月至2019年4月期间接受冠状动脉造影的稳定型心绞痛患者进行本研究评估。总共选择45例孤立性SCF患者作为患者组（SCF组），并纳入50例冠状动脉血流模式正常的患者作为对照组。参与者使用饮食记录提供营养摄入细节，并比较两组的所有数据。
SCF组的高敏C反应蛋白（Hs-CRP）水平（p=0.024）、白细胞计数（p=0.038）和吸烟率（p=0.012）更高。SCF组的总能量（p=0.029）、碳水化合物（p=0.047）和果糖摄入量（p<0.001）也更高。多变量逻辑回归分析表明，较高水平的Hs-CRP、果糖摄入量和吸烟与SCF独立相关。
SCF组显示出较高的果糖摄入量。过量摄入果糖可能在SCF的病理生理学中起作用。
