Alruwaili Nawaf W, Alshdayed Fahad
Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.
Diagnostics (Basel). 2023 Jan 12;13(2):294. doi: 10.3390/diagnostics13020294.
Glucose-galactose malabsorption is a rare inherited autosomal recessive genetic defect. A mutation in the glucose sodium-dependent transporter-1 gene will alter the transportation and absorption of glucose and galactose in the intestine. The defect in the SGLT-1 leads to unabsorbed galactose, glucose, and sodium, which stay in the intestine, leading to dehydration and hyperosmotic diarrhea. Often, glucose-galactose malabsorption patients are highly dependent on fructose, their primary source of carbohydrates. This study aims to investigate all published studies on congenital glucose-galactose malabsorption and fructose malabsorption. One hundred published studies were assessed for eligibility in this study, and thirteen studies were identified and reviewed. Studies showed that high fructose consumption has many health effects and could generate life-threatening complications. None of the published studies included in this review discussed or specified the side effects of fructose consumption as a primary source of carbohydrates in congenital glucose-galactose malabsorption patients.
葡萄糖-半乳糖吸收不良是一种罕见的常染色体隐性遗传缺陷。葡萄糖钠依赖性转运蛋白1基因的突变会改变肠道中葡萄糖和半乳糖的转运与吸收。钠-葡萄糖协同转运蛋白1的缺陷会导致半乳糖、葡萄糖和钠无法被吸收，滞留在肠道中，进而引发脱水和高渗性腹泻。通常，葡萄糖-半乳糖吸收不良患者高度依赖果糖，这是他们碳水化合物的主要来源。本研究旨在调查所有已发表的关于先天性葡萄糖-半乳糖吸收不良和果糖吸收不良的研究。本研究评估了100篇已发表的研究的 eligibility，确定并审查了13项研究。研究表明，大量摄入果糖有许多健康影响，可能会引发危及生命的并发症。本综述纳入的已发表研究均未讨论或明确指出在先天性葡萄糖-半乳糖吸收不良患者中，将果糖作为碳水化合物主要来源的消费的副作用。 （注：原文中“eligibility”此处翻译存疑，可能是“适用性”之类更合适的词，但按要求未做修改）
