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对抗 COVID-19 中抗体和潜在治疗性药物作用的思考。

Perspective on the Role of Antibodies and Potential Therapeutic Drugs to Combat COVID-19.

机构信息

Department of Biotechnology, School of Engineering and Applied Sciences, Bennett University, Plot Nos. 8-11, Tech Zone 2, Greater Noida, Uttar Pradesh, 201310, India.

出版信息

Protein J. 2020 Dec;39(6):631-643. doi: 10.1007/s10930-020-09921-0. Epub 2020 Oct 9.

Abstract

The sudden emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the coronavirus disease of 2019 (COVID-19) has brought the world to a standstill. Thousands of people across the globe are biting the dust with every passing day and yet more are being tested positive for the SARS-CoV-2 infection. In order to dispense this current crisis, numerous treatment options have been tried and tested and many more are still under scrutiny. The development of vaccines may help in the prevention of the global pandemic, however, there is still a need for the development of alternate approaches to combat the disease. In this review we highlight the new discoveries and furtherance in the antibody based therapeutic options and the potent drugs, with special emphasis on the development of the monoclonal and polyclonal antibodies and the repurposed drugs, which may prove to be of significant importance for the treatment of COVID-19, in the days to come. It is an attempt to evaluate the currently presented challenges so as to provide a scope for the ongoing research and assistance in the development of the effective therapeutic options against SARS-CoV-2.

摘要

新型严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)的突然出现导致了 2019 年冠状病毒病(COVID-19),使全球陷入停顿。每天都有数千人因此丧生,还有更多人检测出 SARS-CoV-2 感染呈阳性。为了解决当前的危机,已经尝试和测试了许多治疗方案,还有更多方案仍在审查中。疫苗的开发可能有助于预防全球大流行,但仍需要开发替代方法来对抗这种疾病。在这篇综述中,我们强调了抗体治疗选择和有效药物的新发现和进展,特别强调了单克隆和多克隆抗体以及已批准药物的开发,这些抗体和药物可能对 COVID-19 的治疗具有重要意义。这是为了评估当前面临的挑战,为正在进行的研究提供空间,并为开发针对 SARS-CoV-2 的有效治疗方法提供帮助。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8898/7544555/4e27b6409d81/10930_2020_9921_Fig1_HTML.jpg

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