Department of Medical Biotechnology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Curr Mol Med. 2021;21(7):562-572. doi: 10.2174/1566524020666201203170230.
The coronavirus disease 19 (COVID-19) is a highly pathogenic and transmissible viral disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in the city of Wuhan, Hubei Province, Central China and spread quickly around the world. The genome sequence of SARSCoV- 2 is phylogenetically related to bat-derived severe acute respiratory syndrome-like (SARS-like) coronaviruses; therefore bats could be the possible primary reservoirs. At present, there are no clinically approved vaccines or specific antiviral drugs for COVID- 19. However, several broad-spectrum antiviral drugs have been evaluated against COVID-19 in clinical studies and resulted in the improvement of patients. In this regard, other therapies such as antiviral drugs, antibodies, stem cells and plasma therapy are being studied. In the current study, we reviewed the emergence, pathogenicity and the genome structure of COVID-19 infection. The main focus of this study is on the therapeutic approaches that may be effective against SARS-CoV-2.
新型冠状病毒病（COVID-19）是由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起的一种高致病性和高传染性病毒病，该病毒起源于中国中部湖北省武汉市，并迅速在全球范围内传播。SARS-CoV-2 的基因组序列在系统发育上与源自蝙蝠的严重急性呼吸系统综合征样（SARS 样）冠状病毒有关；因此，蝙蝠可能是可能的主要宿主。目前，尚无针对 COVID-19 的临床批准疫苗或特定抗病毒药物。然而，已经在临床研究中评估了几种广谱抗病毒药物对 COVID-19 的疗效，并使患者病情得到改善。在这方面，其他疗法，如抗病毒药物、抗体、干细胞和血浆疗法正在研究中。在本研究中，我们回顾了 COVID-19 感染的出现、致病性和基因组结构。本研究的主要重点是可能对 SARS-CoV-2 有效的治疗方法。
