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近红外光谱检测到富含脂质的斑块更频繁地暴露于高剪切应力下。

Lipid-rich Plaques Detected by Near-infrared Spectroscopy Are More Frequently Exposed to High Shear Stress.

机构信息

Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands.

PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.

出版信息

J Cardiovasc Transl Res. 2021 Jun;14(3):416-425. doi: 10.1007/s12265-020-10072-x. Epub 2020 Oct 9.

DOI:10.1007/s12265-020-10072-x
PMID:33034862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8219563/
Abstract

High wall shear stress (WSS) and near-infrared spectroscopy (NIRS) detected lipid-rich plaque (LRP) are both known to be associated with plaque destabilization and future adverse cardiovascular events. However, knowledge of spatial co-localization of LRP and high WSS is lacking. This study investigated the co-localization of LRP based on NIRS and high WSS. Fifty-three patients presenting acute coronary syndrome underwent NIRS-intravascular-ultrasound (NIRS-IVUS) imaging of a non-culprit coronary artery. WSS was obtained using WSS profiling in 3D-reconstructions of the coronary arteries based on fusion of IVUS-segmented lumen and CT-derived 3D-centerline. Thirty-eight vessels were available for final analysis and divided into 0.5 mm/45° sectors. LRP sectors, as identified by NIRS, were more often colocalized with high WSS than sectors without LRP. Moreover, there was a dose-dependent relationship between lipid content and high WSS exposure. This study is a first step in understanding the evolution of LRPs to vulnerable plaques. Graphical Abstract.

摘要

高壁切应力（WSS）和近红外光谱（NIRS）检测到富含脂质的斑块（LRP）均与斑块不稳定和未来不良心血管事件相关。然而，LRP 和高 WSS 的空间共存知之甚少。本研究通过 NIRS-血管内超声（NIRS-IVUS）成像研究了基于 NIRS 的 LRP 与高 WSS 的共定位。53 例急性冠状动脉综合征患者行非罪犯冠状动脉的 NIRS-IVUS 成像。WSS 通过 IVUS 分段管腔与 CT 衍生的 3D 中心线融合的冠状动脉 3D 重建中的 WSS 剖面获得。38 个血管可用于最终分析，并分为 0.5mm/45°扇区。与没有 LRP 的区域相比，NIRS 识别的 LRP 区域与高 WSS 更常共存。此外，脂质含量与高 WSS 暴露之间存在剂量依赖性关系。这项研究是了解 LRPs 向易损斑块演变的第一步。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195a/8219563/c3bb53a3fb8f/12265_2020_10072_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195a/8219563/358285d02fa3/12265_2020_10072_Figa_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195a/8219563/98c110257bc3/12265_2020_10072_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195a/8219563/915eb30f9530/12265_2020_10072_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195a/8219563/57f5a5257196/12265_2020_10072_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195a/8219563/c3bb53a3fb8f/12265_2020_10072_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195a/8219563/358285d02fa3/12265_2020_10072_Figa_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195a/8219563/98c110257bc3/12265_2020_10072_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195a/8219563/915eb30f9530/12265_2020_10072_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195a/8219563/57f5a5257196/12265_2020_10072_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195a/8219563/c3bb53a3fb8f/12265_2020_10072_Fig4_HTML.jpg

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3
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