The Assisted Reproduction Center, Northwest Women's and Children's Hospital, No. 73 Houzai Gate, Xincheng District, Xi'an City, Shaanxi Province, China.
Reprod Sci. 2021 Mar;28(3):794-800. doi: 10.1007/s43032-020-00344-x. Epub 2020 Oct 9.
Our objective was to assess whether there is a difference in the pregnancy outcomes in the natural cycle (NC) with spontaneous LH rise compared with modified natural cycle controlled by hCG for final oocyte maturation and ovulation after frozen-thawed embryo transfer (FET). In this retrospective cohort study, we analyzed the clinical outcomes of a total of 1937 patients undergoing FET followed by endometrial preparation with the natural cycle and modified natural cycle. The primary outcome was live birth, and secondary outcomes included miscarriage rate, clinical pregnancy rate, preterm birth rate, and ectopic pregnancy rate. The type of endometrial preparation did not impact live birth (adjusted odds ratio [aOR] 0.92; 95% confidence interval [CI], 0.69-1.23), miscarriage (aOR 0.83; 95%CI, 0.50-1.39), clinical pregnancy (aOR 0.88; 95%CI, 0.66-1.18), preterm birth (aOR 0.91; 95%CI, 0.56-1.50), or ectopic pregnancy (aOR 1.06; 95%CI, 0.29-3.94). In conclusion, in women undergoing FET, natural cycles and modified natural cycles resulted in comparable clinical outcomes.
我们的目的是评估在自然周期（NC）中自发性 LH 升高与通过 hCG 进行改良自然周期控制最终卵母细胞成熟和排卵以进行冻融胚胎移植（FET）后，妊娠结局是否存在差异。在这项回顾性队列研究中，我们分析了总共 1937 名接受 FET 后接受自然周期和改良自然周期进行子宫内膜准备的患者的临床结局。主要结局是活产，次要结局包括流产率、临床妊娠率、早产率和宫外孕率。子宫内膜准备的类型对活产（调整后的优势比[aOR]0.92；95%置信区间[CI]，0.69-1.23）、流产（aOR 0.83；95%CI，0.50-1.39）、临床妊娠（aOR 0.88；95%CI，0.66-1.18）、早产（aOR 0.91；95%CI，0.56-1.50）或宫外孕（aOR 1.06；95%CI，0.29-3.94）没有影响。总之，在接受 FET 的女性中，自然周期和改良自然周期的临床结局相当。
