Department of Obstetrics and Gynecology, University of California Los Angeles, Los Angeles, California.
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California.
Fertil Steril. 2019 Jun;111(6):1145-1150. doi: 10.1016/j.fertnstert.2019.02.018. Epub 2019 Apr 5.
To describe the relationship between interpregnancy interval (IPI) and perinatal outcomes in singleton live births after frozen embryo transfer (FET).
Retrospective analysis of the Society for Assisted Reproductive Technology Clinical Outcome Reporting System cohort including patients with a history of live birth from ART who returned for an FET cycle between 2004 and 2013.
Not applicable.
PATIENT(S): A total of 19,270 singleton live births from FET subsequent to a live birth.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Odds for preterm delivery (<37, <34, <28 weeks) and low birth weight (<2,500, <1,500 g) adjusted for age, body mass index, and history of prior preterm delivery.
RESULT(S): Of 74,456 autologous FET cycles following an index live birth, 24,091 resulted in a repeat live birth, with 19,270 singleton live births. An IPI of <12 months occurred in 19% of cycles. Adjusted odds (aORs) for preterm delivery at <37 weeks were significantly increased for an IPI of <6 months (aOR 2.05, 95% confidence interval [CI] 1.48-2.84), 6 to <12 months (aOR 1.26, 95% CI 1.06-1.49), and 18 to <24 months (aOR 1.23, 95% CI 1.06-1.43) when compared with the reference interval of 12 to <18 months. Additionally, an IPI of <6 months was associated with increased odds for low birth weight (aOR 3.06, 95% CI 2.07-4.52) and very low birth weight (aOR 5.65, 95% CI 2.96-10.84) compared with an IPI of 12 to <18 months.
CONCLUSION(S): In this nationally representative population, an interval from delivery to start of an FET cycle of <12 months is associated with increased odds for preterm delivery among singleton live births. Consistent with data for patients undergoing fresh IVF, the data support delaying FET 12 months from a live birth.
描述冻融胚胎移植（FET）后单胎活产的产后间隔（IPI）与围产期结局的关系。
对 2004 年至 2013 年间接受过活产 ART 并有活产史的患者进行的辅助生殖技术临床结局报告系统队列的回顾性分析。
不适用。
19270 例来自 FET 的单胎活产。
无。
调整年龄、体重指数和既往早产史后，早产（<37 周、<34 周、<28 周）和低出生体重（<2000 克、<1500 克）的比值比（OR）。
在 74456 例自体 FET 周期中，有 24091 例导致重复活产，其中 19270 例为单胎活产。19%的周期 IPI<12 个月。与 12 至<18 个月的参考间隔相比，6 个月（OR 2.05，95%置信区间[CI] 1.48-2.84）、6 至<12 个月（OR 1.26，95% CI 1.06-1.49）和 18 至<24 个月（OR 1.23，95% CI 1.06-1.43）的 IPI 显著增加了早产（<37 周）的校正比值比（aOR）。此外，与 12 至<18 个月的 IPI 相比，6 个月的 IPI 与较低出生体重（aOR 3.06，95% CI 2.07-4.52）和极低出生体重（aOR 5.65，95% CI 2.96-10.84）的几率增加相关。
在这个具有全国代表性的人群中，从分娩到 FET 周期开始的时间<12 个月与单胎活产的早产几率增加有关。与接受新鲜 IVF 治疗的患者数据一致，这些数据支持从活产起等待 12 个月后再进行 FET。
