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Use of protease inhibitors for the prevention of COVID-19.

作者信息

Sagawa Tomoya, Inoue Ken-Ichiro, Takano Hirohisa

机构信息

Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan; Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

School of Nursing, University of Shizuoka, Shizuoka, Japan.

出版信息

Prev Med. 2020 Dec;141:106280. doi: 10.1016/j.ypmed.2020.106280. Epub 2020 Oct 6.

DOI:10.1016/j.ypmed.2020.106280
PMID:33035549
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7537597/
Abstract
摘要

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本文引用的文献

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Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial.氨溴索对新型冠状病毒肺炎患者临床结局及死亡率的影响：一项随机临床试验。
Bioimpacts. 2020;10(4):209-215. doi: 10.34172/bi.2020.27. Epub 2020 Jul 19.
2
Preventing the clinical manifestations and disease progression of coronavirus disease using clinically proven protease inhibitors.使用经临床验证的蛋白酶抑制剂预防冠状病毒病的临床表现和疾病进展。
Crit Care. 2020 Aug 18;24(1):511. doi: 10.1186/s13054-020-03235-4.
3
Nafamostat mesylate treatment in combination with favipiravir for patients critically ill with Covid-19: a case series.甲磺酸那法莫司他联合法匹拉韦治疗新型冠状病毒肺炎危重症患者：病例系列
Crit Care. 2020 Jul 3;24(1):392. doi: 10.1186/s13054-020-03078-z.
4
The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner.抗凝剂萘莫司他在细胞融合检测系统中能强力抑制 SARS-CoV-2 S 蛋白介导的融合，并以细胞类型依赖的方式在体外抑制病毒感染。
Viruses. 2020 Jun 10;12(6):629. doi: 10.3390/v12060629.
5
Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans.非裔美国人 COVID-19 患者的肺部和心脏病理学：来自新奥尔良的尸检系列。
Lancet Respir Med. 2020 Jul;8(7):681-686. doi: 10.1016/S2213-2600(20)30243-5. Epub 2020 May 27.
6
Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection.将黏液溶解型止咳药及跨膜丝氨酸蛋白酶2（TMPRSS2）蛋白酶抑制剂溴己新重新用于预防和治疗新型冠状病毒肺炎（SARS-CoV-2）感染。
Pharmacol Res. 2020 Jul;157:104837. doi: 10.1016/j.phrs.2020.104837. Epub 2020 Apr 22.
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Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5.
8
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Cancer Discov. 2014 Nov;4(11):1310-25. doi: 10.1158/2159-8290.CD-13-1010. Epub 2014 Aug 13.