Carota Giuseppe, Ronsisvalle Simone, Panarello Federica, Tibullo Daniele, Nicolosi Anna, Li Volti Giovanni
Section of Biochemistry, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
Department of Drug Sciences, University of Catania, 95123 Catania, Italy.
J Clin Med. 2021 May 25;10(11):2306. doi: 10.3390/jcm10112306.
Although the epidemic caused by SARS-CoV-2 callings for international attention to develop new effective therapeutics, no specific protocol is yet available, leaving patients to rely on general and supportive therapies. A range of respiratory diseases, including pulmonary fibrosis, have been associated with higher iron levels that may promote the course of viral infection. Recent studies have demonstrated that some natural components could act as the first barrier against viral injury by affecting iron metabolism. Moreover, a few recent studies have proposed the combination of protease inhibitors for therapeutic use against SARS-CoV-2 infection, highlighting the role of viral protease in virus infectivity. In this regard, this review focuses on the analysis, through literature and docking studies, of a number of natural products able to counteract SARS-CoV-2 infection, acting both as iron chelators and protease inhibitors.
尽管由SARS-CoV-2引起的疫情需要国际社会关注以开发新的有效治疗方法，但目前尚无具体方案，患者只能依赖一般和支持性治疗。包括肺纤维化在内的一系列呼吸道疾病与较高的铁水平有关，这可能会促进病毒感染进程。最近的研究表明，一些天然成分可通过影响铁代谢，作为对抗病毒损伤的第一道防线。此外，最近的一些研究提出将蛋白酶抑制剂联合用于治疗SARS-CoV-2感染，凸显了病毒蛋白酶在病毒感染性中的作用。在这方面，本综述重点通过文献和对接研究，分析了一些能够对抗SARS-CoV-2感染的天然产物，它们兼具铁螯合剂和蛋白酶抑制剂的作用。
