Tianjin University of Traditional Chinese Medicine, No.10, Poyang Lake Road, Tuanbo New City, Jinghai District, Tianjin 301617, China.
Tianjin University of Traditional Chinese Medicine, No.10, Poyang Lake Road, Tuanbo New City, Jinghai District, Tianjin 301617, China.
Biomed Pharmacother. 2020 Dec;132:110835. doi: 10.1016/j.biopha.2020.110835. Epub 2020 Oct 6.
Bile acids has gradually become a new focus in various diseases, and ASBT as a transporter responsible for the reabsorption of ileal bile acids, is a key hinge associated to the bile acids-cholesterol balance and bile acids of enterohepatic circulation. The cumulative studies have also shown that ASBT is a promising target for treatment of liver, gallbladder, intestinal and metabolic diseases. This article briefly reviewed the process of bile acids enterohepatic circulation, as well as the regulations of ASBT expression, covering transcription factors, nuclear receptors and gut microbiota. In addition, the relationship between ASBT and various diseases were discussed in this paper. According to the structural classification of ASBT inhibitors, the research status of ASBT inhibitors and potential ASBT inhibitors of traditional Chinese medicine (such resveratrol, jatrorrhizine in Coptis chinensis) were summarized. This review provides a basis for the development of ASBT inhibitors and the treatment strategy of related diseases.
胆汁酸逐渐成为各种疾病的新焦点，而 ASBT 作为负责回肠胆汁酸重吸收的转运体，是与胆汁酸-胆固醇平衡和胆汁酸肠肝循环相关的关键枢纽。累积的研究还表明，ASBT 是治疗肝脏、胆囊、肠道和代谢疾病的有前途的靶点。本文简要综述了胆汁酸肠肝循环的过程，以及 ASBT 表达的调控，包括转录因子、核受体和肠道微生物群。此外，本文还讨论了 ASBT 与各种疾病的关系。根据 ASBT 抑制剂的结构分类，总结了 ASBT 抑制剂的研究现状和中药（如白藜芦醇、黄连中的小檗碱）潜在的 ASBT 抑制剂。本综述为 ASBT 抑制剂的开发和相关疾病的治疗策略提供了依据。
