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海洋天然产物的化学、生物化学和药理学:来自富含化学物质的蓝细菌属。

The Chemistry, Biochemistry and Pharmacology of Marine Natural Products from a Chemically Endowed Genus of Cyanobacteria.

机构信息

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA.

出版信息

Mar Drugs. 2020 Oct 6;18(10):508. doi: 10.3390/md18100508.

Abstract

, a well-known genus of cyanobacteria, is found in various ecological habitats including marine, fresh water, swamps, and rice fields. Species of this genus are associated with many ecological phenomena such as nitrogen fixation, primary productivity through photosynthesis and algal blooms. As a result, there have been a number of investigations of the ecology, natural product chemistry, and biological characteristics of members of this genus. In general, the secondary metabolites of cyanobacteria are considered to be rich sources for drug discovery and development. In this review, the secondary metabolites reported in marine with their associated biological activities or interesting biosynthetic pathways are reviewed, and new insights and perspectives on their metabolic capacities are gained.

摘要

鱼腥藻属是蓝藻门中一个广布的属,分布于各种生态环境中,包括海洋、淡水、沼泽和稻田。该属的物种与许多生态现象有关,如固氮、光合作用产生的初级生产力和藻类大量繁殖。因此,人们对该属成员的生态学、天然产物化学和生物学特性进行了大量的研究。一般来说,蓝藻的次生代谢物被认为是药物发现和开发的丰富来源。在这篇综述中,对海洋鱼腥藻属中报道的次生代谢产物及其相关的生物活性或有趣的生物合成途径进行了综述,并对其代谢能力有了新的认识和观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6226/7600079/dbd00e6af8a8/marinedrugs-18-00508-g001.jpg

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