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Isavuconazole-Animal Data and Clinical Data.艾沙康唑——动物数据与临床数据。
J Fungi (Basel). 2020 Oct 6;6(4):209. doi: 10.3390/jof6040209.
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[Current therapeutic options in invasive mycosis and potential therapeutic role of isavuconazole].[侵袭性真菌病的当前治疗选择及艾沙康唑的潜在治疗作用]
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Role of New Antifungal Agents in the Treatment of Invasive Fungal Infections in Transplant Recipients: Isavuconazole and New Posaconazole Formulations.新型抗真菌药物在移植受者侵袭性真菌感染治疗中的作用：艾沙康唑和新型泊沙康唑制剂
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Isavuconazole to prevent invasive fungal infection in immunocompromised adults: Initial experience at an academic medical centre.伊曲康唑预防免疫功能低下成人侵袭性真菌感染：学术医疗中心的初步经验。
Mycoses. 2019 Aug;62(8):665-672. doi: 10.1111/myc.12924. Epub 2019 May 23.
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Role of isavuconazole in the treatment of invasive fungal infections.艾沙康唑在侵袭性真菌感染治疗中的作用。
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New generation azole antifungals in clinical investigation.新一代唑类抗真菌药物的临床研究。
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Isavuconazole: Pharmacology, Pharmacodynamics, and Current Clinical Experience with a New Triazole Antifungal Agent.艾沙康唑：一种新型三唑类抗真菌药物的药理学、药效学及当前临床经验
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J Mycol Med. 2018 Mar;28(1):15-22. doi: 10.1016/j.mycmed.2018.02.002. Epub 2018 Mar 16.
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Activity of Isavuconazole and Other Azoles against Candida Clinical Isolates and Yeast Model Systems with Known Azole Resistance Mechanisms.艾沙康唑及其他唑类药物对念珠菌临床分离株和具有已知唑类耐药机制的酵母模型系统的活性。
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Fungal Infections and Colonization after Bilateral Lung Transplant: A Six-Year Single-Center Experience.双侧肺移植后的真菌感染与定植：一项为期六年的单中心经验
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Pulmonary aspergillosis: diagnosis and treatment.肺曲霉病：诊断与治疗。
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New Antifungal Agents with Azole Moieties.含唑类基团的新型抗真菌药物
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Special Issue: Antifungal Agents Recently Approved or under Development.特刊：近期获批或正在研发的抗真菌药物
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本文引用的文献

1
endocarditis successfully treated with AngioVac and micafungin followed by long-term isavuconazole suppression.采用AngioVac和米卡芬净成功治疗心内膜炎，随后用艾沙康唑进行长期抑制治疗。
IDCases. 2020 Jun 26;21:e00889. doi: 10.1016/j.idcr.2020.e00889. eCollection 2020.
2
A case of invasive pulmonary mucormycosis resulting from short courses of corticosteroids in a well-controlled diabetic patient.一名血糖控制良好的糖尿病患者因短期使用皮质类固醇引发侵袭性肺毛霉病的病例。
Med Mycol Case Rep. 2020 May 30;29:22-24. doi: 10.1016/j.mmcr.2020.05.008. eCollection 2020 Sep.
3
Isavuconazole Is as Effective as and Better Tolerated Than Voriconazole for Antifungal Prophylaxis in Lung Transplant Recipients.伊曲康唑预防肺移植受者真菌感染的疗效与伏立康唑相当，且耐受性更好。
Clin Infect Dis. 2021 Aug 2;73(3):416-426. doi: 10.1093/cid/ciaa652.
4
Isavuconazole Therapy of Disseminated and Encephalic Infection in an Acute Myeloid Leukemia Patient Treated with Midostaurin.米哚妥林治疗的急性髓系白血病患者的播散性和脑部感染的艾沙康唑治疗
Mediterr J Hematol Infect Dis. 2020 May 1;12(1):e2020026. doi: 10.4084/MJHID.2020.026. eCollection 2020.
5
Successful treatment of Aspergillus fumigatus sternal osteomyelitis with isavuconazole in a heart transplant recipient.心脏移植受者伏立康唑成功治疗烟曲霉胸骨骨髓炎。
Transpl Infect Dis. 2020 Oct;22(5):e13313. doi: 10.1111/tid.13313. Epub 2020 May 23.
6
COVID-19 associated pulmonary aspergillosis.COVID-19 相关肺曲霉病。
Mycoses. 2020 Jun;63(6):528-534. doi: 10.1111/myc.13096. Epub 2020 May 15.
7
Sternal osteomyelitis secondary to after cardiothoracic surgery.心胸外科手术后继发的胸骨骨髓炎。 （你提供的原文“secondary to after cardiothoracic surgery”表述有误，推测正确表述应该是“secondary to cardiothoracic surgery” ，按照纠正后的内容翻译）
Med Mycol Case Rep. 2020 Mar 25;28:16-19. doi: 10.1016/j.mmcr.2020.03.003. eCollection 2020 Jun.
8
Isavuconazole as Primary Antifungal Prophylaxis in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome: An Open-label, Prospective, Phase 2 Study.艾沙康唑作为急性髓系白血病或骨髓增生异常综合征患者的主要抗真菌预防用药：一项开放标签、前瞻性、2期研究。
Clin Infect Dis. 2021 May 18;72(10):1755-1763. doi: 10.1093/cid/ciaa358.
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Pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: The challenge of an optimal therapeutic approach.复发性自发性气胸患者的胸膜曲霉菌病：最佳治疗方法面临的挑战。
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A Single-Center, Open-Label Trial of Isavuconazole Prophylaxis against Invasive Fungal Infection in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation.一项关于异氟康唑预防异基因造血细胞移植患者侵袭性真菌感染的单中心开放标签试验。
Biol Blood Marrow Transplant. 2020 Jun;26(6):1195-1202. doi: 10.1016/j.bbmt.2020.02.009. Epub 2020 Feb 20.

艾沙康唑——动物数据与临床数据。

Isavuconazole-Animal Data and Clinical Data.

作者信息

Pagano Livio, Cattaneo Chiara, Quattrone Martina, Oberti Margherita, Mazzitelli Maria, Trecarichi Enrico Maria

机构信息

Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico A. Gemelli IRCCS, 00168 Roma, Italy.

Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.

出版信息

J Fungi (Basel). 2020 Oct 6;6(4):209. doi: 10.3390/jof6040209.

DOI:10.3390/jof6040209
PMID:33036295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7712195/
Abstract

The treatment of invasive fungal infections has deeply evolved in the last years with the inclusion of new antifungals, mainly new azoles (i.e., posaconazole, isavuconazole), to the therapeutic armamentarium. This review focuses on the role of isavuconazole for treating the most important invasive fungal infections both in animals and humans (hematological and non-hematological patients).

摘要

近年来，随着新的抗真菌药物（主要是新型唑类药物，如泊沙康唑、艾沙康唑）被纳入治疗药物库，侵袭性真菌感染的治疗有了深刻的发展。本综述重点关注艾沙康唑在治疗动物和人类（血液系统和非血液系统患者）最重要的侵袭性真菌感染中的作用。