The Generation R Study Group, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands.
Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands.
Nutrients. 2020 Oct 7;12(10):3057. doi: 10.3390/nu12103057.
Fatty acids might play a role in asthma and allergy development as they can modulate immune responses. We examined among 4260 mother-child pairs participating in a population-based cohort the associations of maternal plasma fatty acid patterns during pregnancy with a child's respiratory and allergy outcomes at school-age. In mid-pregnancy, 22 individual fatty acids were measured from maternal blood. Three patterns were previously identified by principal component analysis: A 'high n-6 polyunsaturated fatty acid (PUFA)', a 'monounsaturated and saturated fatty acid', and a 'high n-3 PUFA' pattern. At the age of 10 years, a child's lung function was assessed by spirometry, current asthma and physician-diagnosed inhalant allergy by questionnaire, and inhalant allergic sensitization by skin prick tests. A higher 'high n-6 PUFA' pattern was associated with a higher forced expiratory volume in 1 s/forced vital capacity and forced expiratory flow after exhaling 75% of forced vital capacity (Z-score difference (95% CI) 0.04 (0, 0.07) and 0.04 (0.01, 0.07), respectively, per SD increase in the fatty acid pattern). We observed no associations of maternal fatty acid patterns with a child's asthma or allergy outcomes. Our results showed limited associations of maternal patterns of high n-6 PUFA concentrations in pregnancy with a better lung function in school-aged children.
脂肪酸可能在哮喘和过敏发展中发挥作用，因为它们可以调节免疫反应。我们在一个基于人群的队列中，对 4260 对母婴进行了研究，调查了母亲在怀孕期间血液中的脂肪酸模式与儿童在学龄期的呼吸道和过敏结果之间的关系。在妊娠中期，从母亲的血液中测量了 22 种单个脂肪酸。通过主成分分析，先前确定了三种模式：“高 n-6 多不饱和脂肪酸（PUFA）”、“单不饱和和饱和脂肪酸”和“高 n-3 PUFA”模式。在 10 岁时，通过肺活量计评估儿童的肺功能，通过问卷调查评估当前哮喘和医生诊断的吸入性过敏，通过皮肤点刺试验评估吸入性过敏致敏。“高 n-6 PUFA”模式较高与 1 秒用力呼气量/用力肺活量和用力呼出 75%用力肺活量后的呼气流量较高有关（每标准差增加脂肪酸模式的 Z 分数差异（95%CI）分别为 0.04（0，0.07）和 0.04（0.01，0.07））。我们没有观察到母亲的脂肪酸模式与儿童哮喘或过敏结果之间的关联。我们的结果表明，妊娠期间母体高 n-6 PUFA 浓度模式与学龄儿童更好的肺功能之间存在有限的关联。
